DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32055 and CYR1

DIOPT Version :9

Sequence 1:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_012529.3	Gene:	CYR1 / 853452	SGDID:	S000003542	Length:	2026	Species:	Saccharomyces cerevisiae

Alignment Length:	642	Identity:	130/642 - (20%)
Similarity:	244/642 - (38%)	Gaps:	178/642 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLLSGVFGKD---LQECEDLG----------NGSYLCREIESFEQLNRYVGKNWKSVKVVN--- 57
            ||||:|....|   :...|||.          ..|:...|.|.....:.:|..:.:::.:..
Yeast   745 LLLLNGYRKSDPLHIMGIEDLSFVFKFLFHPVTPSHFTPEQEQRIMRSEFVHVDLRNMDLTTPPI 809

  Fly    58 ---EHTGIERAEDGELPGLSTLLQLDLSESGGVTLGEKGLQDFKALQKLNLTHAQLDELKSEQFP 119
               :||             |.:..||:|.:..:.|..:.::     ..:.|...::..:::.:||
Yeast   810 IFYQHT-------------SEIESLDVSNNANIFLPLEFIE-----SSIKLLSLRMVNIRASKFP 856

  Fly   120 N----PSEMINFDVSYNDILAITTKLMSGFGNLVYANFSENLIAVIEPNAFRHMKNLRFLDLTTN 180
            :    ..::::.::..|.|..:...:|. ..||...|...|.:..: |..|..:|||:.|||::|
Yeast   857 SNITKAYKLVSLELQRNFIRKVPNSIMK-LSNLTILNLQCNELESL-PAGFVELKNLQLLDLSSN 919

  Fly   181 ----YQENITLGENANLRFLSISNNNLRDFQWCHLRVLPKLEELHLHSNWLEHLDMGIFYALPNL 241
                |.|  .:....||..:.:|.|.::.... ..:.|.||.:::|..|.|..:  |....:.:|
Yeast   920 KFMHYPE--VINYCTNLLQIDLSYNKIQSLPQ-STKYLVKLAKMNLSHNKLNFI--GDLSEMTDL 979

  Fly   242 RVLNVSNNNLFEIKRTLFMAPGEIAPLELLDYSSNIVKVLDDSVFCRLKKLRTLNLWLNQINRIH 306
            |.||:..|.:..||.       ..:.|:.|..:.|.:...:|:    |.|||.|.:..|.|..|.
Yeast   980 RTLNLRYNRISSIKT-------NASNLQNLFLTDNRISNFEDT----LPKLRALEIQENPITSIS 1033

  Fly   307 PRAFLGLSSLQTLHLQGNKISILPDDVFANLTALEKLDLSKNNIQKLGLRVFGERILRKLIYLDL 371
            .:.|.. .::.:|.|...::|.:|.::...|:.||||:|::||:.:|...:   ..|.||::|.:
Yeast  1034 FKDFYP-KNMTSLTLNKAQLSSIPGELLTKLSFLEKLELNQNNLTRLPQEI---SKLTKLVFLSV 1094

  Fly   372 SNNYIADLHPLALSSMPFIKELRLRRN-------------------------------------- 398
            :.|.:..:.| .||.:..::.|.|..|
Yeast  1095 ARNKLEYIPP-ELSQLKSLRTLDLHSNNIRDFVDGMENLELTSLNISSNAFGNSSLENSFYHNMS 1158

  Fly   399 ---------------------------------RLVSLDLRMFAPLRQLQLLTINE-----NRLE 425
                                             ::::|....|:.:..::|.:|.|     |:|.
Yeast  1159 YGSKLSKSLMFFIAADNQFDDAMWPLFNCFVNLKVLNLSYNNFSDVSHMKLESITELYLSGNKLT 1223

  Fly   426 EIDGEILDTLDRLNHLELNNNRLTFLPDLKSSQNLLQLR-----------NITLEGNPWQCLCLD 479
            .:.|:.:.....|..|.||:|::..||  ....||.||.           ||:.....|
Yeast  1224 TLSGDTVLKWSSLKTLMLNSNQMLSLP--AELSNLSQLSVFDVGANQLKYNISNYHYDW------ 1280

  Fly   480 EITSWLNGRHVSYARPSSAYFSGRKPLCVVT----PMDKCLRD---LQETKAQGIVE 529
               :|.|.:.:.|..     |||.:...:.:    .:|..|.|   |.:.|..|:::
Yeast  1281 ---NWRNNKELKYLN-----FSGNRRFEIKSFISHDIDADLSDLTVLPQLKVLGLMD 1329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380	4/22 (18%)
		leucine-rich repeat	100..123	CDD:275380	3/26 (12%)
		LRR_8	128..180	CDD:290566	15/51 (29%)
		leucine-rich repeat	128..147	CDD:275380	3/18 (17%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..192	CDD:275380	7/23 (30%)
		LRR_RI	<187..400	CDD:238064	55/283 (19%)
		LRR_8	192..251	CDD:290566	16/58 (28%)
		leucine-rich repeat	193..216	CDD:275380	4/22 (18%)
		leucine-rich repeat	217..240	CDD:275380	5/22 (23%)
		leucine-rich repeat	241..267	CDD:275380	7/25 (28%)
		leucine-rich repeat	268..291	CDD:275380	5/22 (23%)
		LRR_8	290..350	CDD:290566	19/59 (32%)
		leucine-rich repeat	292..315	CDD:275380	7/22 (32%)
		leucine-rich repeat	316..339	CDD:275380	5/22 (23%)
		LRR_8	340..400	CDD:290566	19/130 (15%)
		leucine-rich repeat	340..365	CDD:275380	9/24 (38%)
		leucine-rich repeat	366..389	CDD:275380	6/22 (27%)
		leucine-rich repeat	390..413	CDD:275380	5/93 (5%)
		LRR_8	391..448	CDD:290566	16/132 (12%)
		leucine-rich repeat	414..437	CDD:275380	6/27 (22%)
CYR1	NP_012529.3	Ad_cyc_g-alpha	368..418	CDD:369912
		RA_PHLPP_like	678..776	CDD:340473	9/30 (30%)
		PLN00113	792..>1273	CDD:215061	103/523 (20%)
		leucine-rich repeat	796..817	CDD:275380	2/33 (6%)
		leucine-rich repeat	818..839	CDD:275380	4/25 (16%)
		leucine-rich repeat	840..864	CDD:275380	3/23 (13%)
		leucine-rich repeat	865..887	CDD:275380	3/22 (14%)
		leucine-rich repeat	888..910	CDD:275380	5/22 (23%)
		leucine-rich repeat	911..933	CDD:275380	7/23 (30%)
		leucine-rich repeat	934..956	CDD:275380	4/22 (18%)
		leucine-rich repeat	957..978	CDD:275380	5/22 (23%)
		leucine-rich repeat	979..1018	CDD:275380	12/49 (24%)
		leucine-rich repeat	1019..1041	CDD:275380	7/22 (32%)
		leucine-rich repeat	1042..1065	CDD:275380	5/22 (23%)
		leucine-rich repeat	1066..1088	CDD:275380	9/24 (38%)
		leucine-rich repeat	1089..1111	CDD:275380	6/22 (27%)
		leucine-rich repeat	1167..1187	CDD:275380	0/19 (0%)
		leucine-rich repeat	1191..1211	CDD:275380	3/19 (16%)
		leucine-rich repeat	1236..1258	CDD:275380	9/23 (39%)
		leucine-rich repeat	1259..1287	CDD:275380	6/36 (17%)
		PP2C	1374..1617	CDD:395385
		CYCc	1613..1825	CDD:214485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960