DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32055 and Cpn2

DIOPT Version :9

Sequence 1:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_082180.2	Gene:	Cpn2 / 71756	MGIID:	1919006	Length:	547	Species:	Mus musculus

Alignment Length:	428	Identity:	124/428 - (28%)
Similarity:	201/428 - (46%)	Gaps:	42/428 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 QLDELKSEQFPNPSEMINFDVSYNDILAITTKLMSGFGNLVYANFSENLIAVIEPNAFRHMKNLR 173
            ||.::..:..|:.::::..:.::.   .:.|:..||..||....|....:..:||:||..:..|:
Mouse    39 QLADIPPDIPPHITDIVFVETAFT---TVRTRAFSGSPNLTKVVFLNTQVRHLEPDAFGGLPRLQ 100

  Fly   174 FLDLTTNYQENITLGENANLRFLSISNNNLRDFQ---------WCHLRVLPKLEELHLHSNWLEH 229
            .|::|.:...|::....:||.  |:....| ||.         :||:.:   ||.|.|..|.|..
Mouse   101 DLEITGSPVSNLSAHIFSNLS--SLEKLTL-DFDRLAGLPEDLFCHMDI---LESLQLQGNQLRT 159

  Fly   230 LDMGIFYALPNLRVLNVSNNNLFEIKRTLFMAPGEIAPLELLDYSSNIVKVLDDSVFCRLKKLRT 294
            |...:|.:|.:||.||::.|.|.::.:..|.:   :..|::|..|:|::..|.:.....|..|:.
Mouse   160 LPGRLFQSLRDLRTLNLAQNLLTQLPKGAFQS---LTGLQMLKLSNNMLARLPEGALGSLSSLQE 221

  Fly   295 LNLWLNQINRIHPRAFLGLSSLQTLHLQGNKISILPDDVFANLTALEKLDLSKNNIQKLGLRVFG 359
            |.|..|.|..:.|..|..|.||:.|.||.|.|..||..:|::|..|..|.|..|.::.|...:|.
Mouse   222 LFLDGNAITELSPHLFSQLFSLEMLWLQHNAICHLPVSLFSSLHNLTFLSLKDNALRTLPEGLFA 286

  Fly   360 ERILRKLIYLDLSNNYIADLHPLALSSMPFIKELRLRRNRLVSLDLRMFAPLRQLQLLTINENRL 424
            ..  :.|::|.||.|.:..:...|.:::..:..|.|..|.:..|...:|..|.||..|:::.|.|
Mouse   287 HN--QGLLHLSLSYNQLETIPEGAFTNLSRLVSLTLSHNAITDLPEHVFRNLEQLVKLSLDSNNL 349

  Fly   425 EEIDGEILDTLDRLNHLELNNNRLTFLPDLKSSQNLLQLRNITLEGNPWQCLC-LDEITSWL--- 485
            ..:...:...|.||..|.|:.|:||.||......| ..|.|:.|.||||||.| |..:||||
Mouse   350 TALHPALFHNLSRLQLLNLSRNQLTTLPGGIFDTN-YDLFNLALLGNPWQCDCHLSYLTSWLRLY 413

  Fly   486 ----NGRHVSYARPSSAYFSGR--------KPLCVVTP 511
                :..|...|.|  ||..|:        :.:|.|.|
Mouse   414 NNQISNTHTFCAGP--AYLKGQLVPNLKQEQLICPVNP 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380
		leucine-rich repeat	100..123	CDD:275380	3/13 (23%)
		LRR_8	128..180	CDD:290566	13/51 (25%)
		leucine-rich repeat	128..147	CDD:275380	3/18 (17%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		leucine-rich repeat	172..192	CDD:275380	4/19 (21%)
		LRR_RI	<187..400	CDD:238064	64/221 (29%)
		LRR_8	192..251	CDD:290566	22/67 (33%)
		leucine-rich repeat	193..216	CDD:275380	7/31 (23%)
		leucine-rich repeat	217..240	CDD:275380	9/22 (41%)
		leucine-rich repeat	241..267	CDD:275380	7/25 (28%)
		leucine-rich repeat	268..291	CDD:275380	6/22 (27%)
		LRR_8	290..350	CDD:290566	23/59 (39%)
		leucine-rich repeat	292..315	CDD:275380	8/22 (36%)
		leucine-rich repeat	316..339	CDD:275380	10/22 (45%)
		LRR_8	340..400	CDD:290566	15/59 (25%)
		leucine-rich repeat	340..365	CDD:275380	6/24 (25%)
		leucine-rich repeat	366..389	CDD:275380	6/22 (27%)
		leucine-rich repeat	390..413	CDD:275380	6/22 (27%)
		LRR_8	391..448	CDD:290566	17/56 (30%)
		leucine-rich repeat	414..437	CDD:275380	5/22 (23%)
Cpn2	NP_082180.2	LRRNT	21..52	CDD:214470	3/12 (25%)
		LRR_8	73..133	CDD:290566	17/62 (27%)
		leucine-rich repeat	75..98	CDD:275380	6/22 (27%)
		LRR 1	98..119		4/20 (20%)
		leucine-rich repeat	99..122	CDD:275380	6/24 (25%)
		LRR_8	121..181	CDD:290566	20/65 (31%)
		LRR 2	122..143		4/21 (19%)
		leucine-rich repeat	123..146	CDD:275380	5/23 (22%)
		LRR 3	146..167		8/23 (35%)
		leucine-rich repeat	147..170	CDD:275380	9/22 (41%)
		LRR_RI	149..374	CDD:238064	68/229 (30%)
		LRR 4	170..191		7/20 (35%)
		LRR_8	171..229	CDD:290566	17/60 (28%)
		leucine-rich repeat	171..194	CDD:275380	7/25 (28%)
		LRR 5	194..215		5/20 (25%)
		leucine-rich repeat	195..218	CDD:275380	6/22 (27%)
		LRR_8	217..277	CDD:290566	23/59 (39%)
		LRR 6	218..239		7/20 (35%)
		leucine-rich repeat	219..242	CDD:275380	8/22 (36%)
		LRR 7	242..263		10/20 (50%)
		leucine-rich repeat	243..266	CDD:275380	10/22 (45%)
		LRR_8	266..325	CDD:290566	15/60 (25%)
		LRR 8	266..287		6/20 (30%)
		leucine-rich repeat	267..290	CDD:275380	6/24 (25%)
		LRR 9	290..311		6/20 (30%)
		leucine-rich repeat	291..314	CDD:275380	6/22 (27%)
		LRR_8	313..373	CDD:290566	17/59 (29%)
		LRR 10	314..335		5/20 (25%)
		leucine-rich repeat	315..338	CDD:275380	6/22 (27%)
		LRR 11	338..359		5/20 (25%)
		leucine-rich repeat	339..360	CDD:275380	4/20 (20%)
		LRR 12	362..383		9/20 (45%)
		leucine-rich repeat	363..382	CDD:275380	8/18 (44%)
		LRRCT	395..436	CDD:214507	17/42 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000