DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32055 and Vasn

DIOPT Version :9

Sequence 1:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001102852.1	Gene:	Vasn / 679921	RGDID:	1598149	Length:	673	Species:	Rattus norvegicus

Alignment Length:	306	Identity:	88/306 - (28%)
Similarity:	130/306 - (42%)	Gaps:	55/306 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 VLPKLEELHLHSNWLEHLDMGIFYALPNLRVLNVSNNNLFEIKRTLFMAPGEIAPLELLDYSSNI 277
            |.|....|::..|.:..||:|.|...|.|::|::|.|.:..:...:|.   .:..|..||.::|.
  Rat    51 VPPDTVGLYIFENGITTLDVGCFAGFPGLQLLDLSQNQITSLPGGIFQ---PLVNLSNLDLTANK 112

  Fly   278 VKVLDDSVFCRLKKLRTLNLWLNQINRIHPRAFLGLSSLQTLHLQGNKISILPDDVFANLTALEK 342
            :..:.:..|..|::|..|.|..|:|..|.|.||..|..|..|.|..|::.:||.   .:|..|..
  Rat   113 LHEISNETFRGLRRLERLYLGKNRIRHIQPGAFDALDHLLELKLPDNELRVLPP---LHLPRLLL 174

  Fly   343 LDLSKNNIQK------------------LGLRVFGERI---LRKLIYLDLSNNYIADLHPLALSS 386
            ||||.|:|..                  ||||...|.:   ||.|..||:|:|.:..: |..:..
  Rat   175 LDLSHNSIPALEAGILDTANVEALRLAGLGLRQLDEGLFGRLRNLHDLDVSDNQLGHM-PSVIQG 238

  Fly   387 MPFIKELRLRRNRLVSLDLRMFAPLRQLQLLTINENRLEEIDGEILDTLDRLNHLELNNNRLTFL 451
            :..:..|||..|                       .|:.:|..|.|..|..|..|:::|..|..|
  Rat   239 LRGLTRLRLAGN-----------------------TRIAQIRPEDLAGLTALQELDVSNLSLQAL 280

  Fly   452 P-DLKSSQNLLQLRNITLEGNPWQCLC-LDEITSWLNGRHVSYARP 495
            | ||.|.  ..:||.:....||:.||| |.....|:...||..|.|
  Rat   281 PSDLSSL--FPRLRLLAAARNPFNCLCPLSWFGPWVRESHVVLASP 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380
		leucine-rich repeat	100..123	CDD:275380
		LRR_8	128..180	CDD:290566
		leucine-rich repeat	128..147	CDD:275380
		leucine-rich repeat	148..171	CDD:275380
		leucine-rich repeat	172..192	CDD:275380
		LRR_RI	<187..400	CDD:238064	61/207 (29%)
		LRR_8	192..251	CDD:290566	13/37 (35%)
		leucine-rich repeat	193..216	CDD:275380	1/2 (50%)
		leucine-rich repeat	217..240	CDD:275380	6/22 (27%)
		leucine-rich repeat	241..267	CDD:275380	5/25 (20%)
		leucine-rich repeat	268..291	CDD:275380	6/22 (27%)
		LRR_8	290..350	CDD:290566	23/59 (39%)
		leucine-rich repeat	292..315	CDD:275380	10/22 (45%)
		leucine-rich repeat	316..339	CDD:275380	7/22 (32%)
		LRR_8	340..400	CDD:290566	24/80 (30%)
		leucine-rich repeat	340..365	CDD:275380	13/45 (29%)
		leucine-rich repeat	366..389	CDD:275380	6/22 (27%)
		leucine-rich repeat	390..413	CDD:275380	4/22 (18%)
		LRR_8	391..448	CDD:290566	12/56 (21%)
		leucine-rich repeat	414..437	CDD:275380	5/22 (23%)
Vasn	NP_001102852.1	LRRNT	25..55	CDD:214470	2/3 (67%)
		leucine-rich repeat	35..57	CDD:275380	2/5 (40%)
		PPP1R42	58..257	CDD:411060	60/228 (26%)
		leucine-rich repeat	58..78	CDD:275380	6/19 (32%)
		leucine-rich repeat	79..102	CDD:275380	5/25 (20%)
		leucine-rich repeat	103..126	CDD:275380	6/22 (27%)
		leucine-rich repeat	127..150	CDD:275380	10/22 (45%)
		leucine-rich repeat	151..194	CDD:275380	14/45 (31%)
		leucine-rich repeat	195..218	CDD:275380	6/22 (27%)
		leucine-rich repeat	219..241	CDD:275380	6/22 (27%)
		leucine-rich repeat	242..266	CDD:275380	9/46 (20%)
		leucine-rich repeat	267..290	CDD:275380	9/24 (38%)
		PCC	271..>350	CDD:188093	20/56 (36%)
		EGF	410..441	CDD:394967
		fn3	469..546	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910