DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32055 and igfals

DIOPT Version :9

Sequence 1:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	XP_003198203.1	Gene:	igfals / 570758	ZFINID:	ZDB-GENE-061009-25	Length:	614	Species:	Danio rerio

Alignment Length:	533	Identity:	148/533 - (27%)
Similarity:	238/533 - (44%)	Gaps:	77/533 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQALQVLALLLLSGVFGKDLQECEDLGNGSYLCREIESFEQLNRYVGKNWKSVKVVN-EHTGIER 64
            ::.|.:.:.||:|    .|......|.:.::|..|..:...|:..|.:...::..:: .:..:.|
Zfish   108 LEFLNLQSSLLVS----LDAHAFRGLNSLAHLHLERNNLRSLSGLVFQGTSNLATLSLNNNQMFR 168

  Fly    65 AEDGELPGLSTLLQLDLSESGGVTLGEKGLQDFKALQKLNLTHAQLDELKSEQFPNPSEMINFDV 129
            .:|....|:|.:..|:|..:....|.|.|.||...|::|.|...:|..|:.:.|...:|:...|:
Zfish   169 IDDRLFAGMSHMWLLNLGWNLLSVLPETGFQDLHGLRELILAGNRLAYLQPQLFQGLNELKELDL 233

  Fly   130 SYNDILAITTKLMSGFGNLVYANFSENLIAVIEPNAFRHMKNLRFLDLTTN----YQENITLGEN 190
            :.|.:..|...:......|......:|.|..:.|.||..||:||:|||:.|    ..:...:|..
Zfish   234 TGNYLKVIKANVFLKLPKLQKLYLGQNQIVTVAPRAFVGMKSLRWLDLSRNRLTVLHDETFIGLQ 298

  Fly   191 ANLRFLSISNNNLRDFQWCHLRVLPKLEELHLHSNWLEHLDMGIFYALPNLRVLNVSNNNLFEIK 255
             :|..|.:|||::...:....|.|..||||.|:.|.:..|.:.:|..|.:|.|||:.||.|.|.:
Zfish   299 -SLHVLRLSNNSINSLRPGTFRDLQYLEELCLYHNQIRALGVRVFEGLGHLEVLNLENNRLQEAR 362

  Fly   256 RTLFMAPGEIAPLELLDYSSNIVKVLDDSVFCRLKKLRTLNLWLNQINRIHPRAFLGLSSLQTLH 320
            ...||....:|.::|   :.:....|.|.||..|.||.:::|..:.:.::..::|.||:.|:.|.
Zfish   363 MGTFMGLNHLAVMKL---TGSCFHSLPDQVFKGLSKLHSIHLDRSCLTKVSSQSFSGLTGLRRLF 424

  Fly   321 LQGNKISILPDDVFANLTALEKLDLSKNNIQKLGLRVF-GERILRKLIYLDLSNNYIADLHPLAL 384
            ||.|.||::....|..|..|::|||..|.:..:....| |   |:.|.||.||.|.:.:|...||
Zfish   425 LQHNNISLVERQSFVELQRLQQLDLRFNKLTTITSNTFYG---LKNLDYLLLSGNLLHNLPAEAL 486

  Fly   385 SSMPFIKELRLRRNRLVSLDLRMFAPLRQLQLLTINENRLEEIDGEILDTLDRLNHLELNNNRLT 449
                                    .||:.|..|.::.|:||.|....:..|.||.:|.|.:|.|.
Zfish   487 ------------------------LPLQHLSWLDLSGNKLELILNATIYMLPRLRYLNLKDNILV 527

  Fly   450 FLPDLKSSQNLLQLRNITLEGNPWQCLC----------------------LDE-------ITSWL 485
            .|| :...::|.||   .|.||.|:|.|                      |.|       ||.:.
Zfish   528 NLP-VSIPESLDQL---WLSGNNWKCDCSAKPFRDFILQKPQVVPLQVEMLGEGEEPHTLITVYN 588

  Fly   486 NGRHVSYARPSSA 498
            |   |:.|.||||
Zfish   589 N---VTCASPSSA 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380	7/22 (32%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		LRR_8	128..180	CDD:290566	16/51 (31%)
		leucine-rich repeat	128..147	CDD:275380	3/18 (17%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		leucine-rich repeat	172..192	CDD:275380	7/23 (30%)
		LRR_RI	<187..400	CDD:238064	66/213 (31%)
		LRR_8	192..251	CDD:290566	22/58 (38%)
		leucine-rich repeat	193..216	CDD:275380	7/22 (32%)
		leucine-rich repeat	217..240	CDD:275380	9/22 (41%)
		leucine-rich repeat	241..267	CDD:275380	10/25 (40%)
		leucine-rich repeat	268..291	CDD:275380	6/22 (27%)
		LRR_8	290..350	CDD:290566	20/59 (34%)
		leucine-rich repeat	292..315	CDD:275380	5/22 (23%)
		leucine-rich repeat	316..339	CDD:275380	9/22 (41%)
		LRR_8	340..400	CDD:290566	17/60 (28%)
		leucine-rich repeat	340..365	CDD:275380	8/25 (32%)
		leucine-rich repeat	366..389	CDD:275380	9/22 (41%)
		leucine-rich repeat	390..413	CDD:275380	2/22 (9%)
		LRR_8	391..448	CDD:290566	14/56 (25%)
		leucine-rich repeat	414..437	CDD:275380	7/22 (32%)
igfals	XP_003198203.1	LRRNT	48..81	CDD:279764
		leucine-rich repeat	65..83	CDD:275380
		leucine-rich repeat	84..107	CDD:275380
		LRR_8	85..142	CDD:290566	8/37 (22%)
		leucine-rich repeat	108..131	CDD:275380	6/26 (23%)
		LRR_8	131..214	CDD:290566	18/82 (22%)
		leucine-rich repeat	132..155	CDD:275380	4/22 (18%)
		leucine-rich repeat	156..203	CDD:275380	11/46 (24%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		LRR_RI	<219..456	CDD:238064	73/240 (30%)
		LRR_8	227..286	CDD:290566	18/58 (31%)
		leucine-rich repeat	228..251	CDD:275380	3/22 (14%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		LRR_8	274..334	CDD:290566	21/60 (35%)
		leucine-rich repeat	276..299	CDD:275380	7/23 (30%)
		leucine-rich repeat	300..323	CDD:275380	7/22 (32%)
		leucine-rich repeat	324..347	CDD:275380	9/22 (41%)
		leucine-rich repeat	348..369	CDD:275380	10/20 (50%)
		LRR_8	371..430	CDD:290566	18/61 (30%)
		leucine-rich repeat	396..419	CDD:275380	5/22 (23%)
		LRR_8	418..478	CDD:290566	23/62 (37%)
		leucine-rich repeat	420..443	CDD:275380	9/22 (41%)
		leucine-rich repeat	444..467	CDD:275380	8/25 (32%)
		LRR_8	466..524	CDD:290566	22/81 (27%)
		leucine-rich repeat	468..486	CDD:275380	7/17 (41%)
		leucine-rich repeat	492..515	CDD:275380	7/22 (32%)
		leucine-rich repeat	516..540	CDD:275380	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D299282at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920