DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32055 and Tl

DIOPT Version :9

Sequence 1:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster

Alignment Length:	379	Identity:	106/379 - (27%)
Similarity:	174/379 - (45%)	Gaps:	58/379 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 DILAITTKLMSGFGNLVYANFSEN--LIAVIEPNAF-RHMKNLRFLDLTTNYQE---NITLGE-- 189
            |.|.....:||.:..:..|| :||  ....|:|..: :.|.||..   ||:||:   .:.:||
  Fly    40 DGLCQCAPIMSEYEIICPAN-AENPTFRLTIQPKDYVQIMCNLTD---TTDYQQLPKKLRIGEVD 100

  Fly   190 ---------------NANLRFLSI---------SNNNLRDFQWCHLRVLPKLEELHLHSNWLEHL 230
                           .:.|.:|.|         |:|...:....||..|..|:.....:..|.|:
  Fly   101 RVQMRRCMLPGHTPIASILDYLGIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHI 165

  Fly   231 DMGIFYALPNLRVLNVSNNNLFEIKRTLFMAPGEIAPLELLDYSSNIVKVLDDSVFCRLKKLRTL 295
            ...:...:.||..|.: ..|:.|:...||   .::..||.:::.||.::.:...:|.::.||:.|
  Fly   166 PANLLTDMRNLSHLEL-RANIEEMPSHLF---DDLENLESIEFGSNKLRQMPRGIFGKMPKLKQL 226

  Fly   296 NLWLNQINRIHPRAFLGLSSLQTLHLQGNKISILPDDVFANLTALEKLDLSKNNIQKLGLRVFGE 360
            |||.||::.:....|.|.:|:..:.:..|.|..||.||||:||.:..::||.|..:.|...:|..
  Fly   227 NLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDH 291

  Fly   361 RILRKLIYLDLSNNYIADLHPLA------LSSMPFIKELRLRRNRLVSLDLRMFAPLRQLQLLTI 419
            .  :.|..:.|.||.:    |||      .::.|.::.||||. .|.||...:|....|:..:::
  Fly   292 N--KHLNEVRLMNNRV----PLATLPSRLFANQPELQILRLRA-ELQSLPGDLFEHSTQITNISL 349

  Fly   420 NENRLEEIDGEILDTLDRLNHLELNNNRLTFLPD--LKSSQNLLQLRNITLEGN 471
            .:|.|:.:...:|:....|..|:|:|||||.|||  ...:.||..||   ||.|
  Fly   350 GDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLR---LEDN 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380
		leucine-rich repeat	100..123	CDD:275380
		LRR_8	128..180	CDD:290566	14/49 (29%)
		leucine-rich repeat	128..147	CDD:275380	4/13 (31%)
		leucine-rich repeat	148..171	CDD:275380	7/25 (28%)
		leucine-rich repeat	172..192	CDD:275380	7/39 (18%)
		LRR_RI	<187..400	CDD:238064	63/244 (26%)
		LRR_8	192..251	CDD:290566	14/67 (21%)
		leucine-rich repeat	193..216	CDD:275380	8/31 (26%)
		leucine-rich repeat	217..240	CDD:275380	3/22 (14%)
		leucine-rich repeat	241..267	CDD:275380	6/25 (24%)
		leucine-rich repeat	268..291	CDD:275380	5/22 (23%)
		LRR_8	290..350	CDD:290566	24/59 (41%)
		leucine-rich repeat	292..315	CDD:275380	9/22 (41%)
		leucine-rich repeat	316..339	CDD:275380	9/22 (41%)
		LRR_8	340..400	CDD:290566	17/65 (26%)
		leucine-rich repeat	340..365	CDD:275380	5/24 (21%)
		leucine-rich repeat	366..389	CDD:275380	7/28 (25%)
		leucine-rich repeat	390..413	CDD:275380	8/22 (36%)
		LRR_8	391..448	CDD:290566	17/56 (30%)
		leucine-rich repeat	414..437	CDD:275380	3/22 (14%)
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	19/62 (31%)
		leucine-rich repeat	176..198	CDD:275380	6/25 (24%)
		leucine-rich repeat	199..222	CDD:275380	5/22 (23%)
		LRR_RI	216..542	CDD:238064	65/195 (33%)
		LRR_8	221..281	CDD:290566	24/59 (41%)
		leucine-rich repeat	223..270	CDD:275380	19/46 (41%)
		leucine-rich repeat	271..294	CDD:275380	5/24 (21%)
		leucine-rich repeat	295..320	CDD:275380	7/28 (25%)
		leucine-rich repeat	321..343	CDD:275380	8/22 (36%)
		LRR_8	342..402	CDD:290566	22/62 (35%)
		leucine-rich repeat	344..367	CDD:275380	3/22 (14%)
		leucine-rich repeat	368..391	CDD:275380	11/22 (50%)
		LRR_8	390..450	CDD:290566	7/14 (50%)
		leucine-rich repeat	392..415	CDD:275380	6/12 (50%)
		leucine-rich repeat	416..439	CDD:275380
		leucine-rich repeat	440..474	CDD:275380
		leucine-rich repeat	475..498	CDD:275380
		LRR_8	477..534	CDD:290566
		leucine-rich repeat	499..520	CDD:275380
		leucine-rich repeat	523..552	CDD:275380
		LRRCT	561..619	CDD:214507
		LRRNT	631..667	CDD:214470
		leucine-rich repeat	664..693	CDD:275380
		LRR_8	669..726	CDD:290566
		leucine-rich repeat	694..715	CDD:275380
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453584
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840