DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32055 and CG4950

DIOPT Version :9

Sequence 1:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	127/549 - (23%)
Similarity:	210/549 - (38%)	Gaps:	167/549 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQVLALLLLSGVFGKDLQECEDLGNGSYL-CREIESFEQLNRYVGKNWKSVKVVNEH----TG-- 61
            |:|:.:|:|:      :..|:..|....| |.|.:|...::            |||.    ||
  Fly     8 LEVIVILILA------ISSCDGSGGDIPLRCDEYDSMGYMD------------VNEAFCTVTGFT 54

  Fly    62 --------IERAEDGELPGL-----STLL--------------QLDLSESGGVTLGEKGLQDFKA 99
                    |:....|.:...     ||||              .||:|.:..:.|..........
  Fly    55 VTHSQNVVIKNIPPGNMVKFMKFYESTLLYMPFHLFETFPYLKTLDVSNTNILELTRNAFSAASN 119

  Fly   100 LQKLNLTHAQLDELKSEQFPNPSEMINFDVSYNDILAITTKLMSGF---------GNLV------ 149
            |..|||.:..|..:::..|...:.::..|:|||:|.:::.....|.         |||:
  Fly   120 LTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAFCGLHTISQIYLTGNLLKELHND 184

  Fly   150 ---------YANFSENLIAVIEPNAFRHMKNLRFLDLTTN---YQENITLGENANLRFLSISNNN 202
                     ..:|..||:..|:|..||:|:.::.::|:.|   :....|..:.|:|..|.:|.|.
  Fly   185 IFKDNEYLEKVSFEGNLLTSIQPEVFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNE 249

  Fly   203 LRDFQWCHLRVLPKLEELHLHSNWLEHLDMGIFYALPNLRVLNVSNNNLFEIKRTLFMAPGEIAP 267
            |::||.....:   :.:|||.:|:|.:|.:..      .|.:..|:|.:.|
  Fly   250 LKNFQLTEKNI---VHQLHLDNNYLTNLTINA------TRFVRASHNQISE-------------- 291

  Fly   268 LELLDYSSNIVKVLDDSVFCRLKKLRTLNLWLNQINRIHPRAFLGLSSLQTLHLQGNKISILPDD 332
                                         |:|:|  .:|         ::||.|..||:|.:.:
  Fly   292 -----------------------------LFLHQ--SLH---------IETLDLSANKLSSISN- 315

  Fly   333 VFANLTALEKLDLSKNNIQKLGLRVFGERILRKLIYLDLSNNYIADLHPLALSSMPFIKELRLRR 397
             ..|:|.:..||:|.|.|..|.:..|.:  |::|..|:|....|.:|.....|...:::||.|..
  Fly   316 -ITNITHMLYLDVSDNPIGPLNISTFSQ--LKRLRGLNLRGTGIRELKFGMFSKQKYLEELDLSF 377

  Fly   398 NRLVSLDLRMFAP-LRQLQLLTINENRLEEIDGE--ILDTLDRLNHLELNNNR--------LTFL 451
            |.|..|:|.||.| |..|:...|:.|.|.|:.|.  ..:...:|..|.::.||        |...
  Fly   378 NNLTILNLDMFVPYLTNLKKFLIDGNGLTELQGNRTFSEAFPQLQKLGVSRNRFNCSYLHHLLIP 442

  Fly   452 PDLKSSQNLLQLRNITLEGNPWQCLCLDE 480
            |.|..|..|    ||..:.|      |||
  Fly   443 PSLPESVVL----NIEPDTN------LDE 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380	6/36 (17%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		LRR_8	128..180	CDD:290566	18/75 (24%)
		leucine-rich repeat	128..147	CDD:275380	6/27 (22%)
		leucine-rich repeat	148..171	CDD:275380	9/37 (24%)
		leucine-rich repeat	172..192	CDD:275380	3/22 (14%)
		LRR_RI	<187..400	CDD:238064	48/212 (23%)
		LRR_8	192..251	CDD:290566	16/58 (28%)
		leucine-rich repeat	193..216	CDD:275380	7/22 (32%)
		leucine-rich repeat	217..240	CDD:275380	6/22 (27%)
		leucine-rich repeat	241..267	CDD:275380	4/25 (16%)
		leucine-rich repeat	268..291	CDD:275380	0/22 (0%)
		LRR_8	290..350	CDD:290566	16/59 (27%)
		leucine-rich repeat	292..315	CDD:275380	4/22 (18%)
		leucine-rich repeat	316..339	CDD:275380	7/22 (32%)
		LRR_8	340..400	CDD:290566	18/59 (31%)
		leucine-rich repeat	340..365	CDD:275380	8/24 (33%)
		leucine-rich repeat	366..389	CDD:275380	6/22 (27%)
		leucine-rich repeat	390..413	CDD:275380	11/23 (48%)
		LRR_8	391..448	CDD:290566	21/67 (31%)
		leucine-rich repeat	414..437	CDD:275380	6/24 (25%)
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	4/22 (18%)
		LRR_8	118..178	CDD:290566	14/59 (24%)
		leucine-rich repeat	120..143	CDD:275380	6/22 (27%)
		leucine-rich repeat	144..167	CDD:275380	6/22 (27%)
		leucine-rich repeat	168..191	CDD:275380	3/22 (14%)
		LRR_8	192..250	CDD:290566	16/57 (28%)
		leucine-rich repeat	192..215	CDD:275380	8/22 (36%)
		LRR_RI	<207..432	CDD:238064	72/291 (25%)
		leucine-rich repeat	216..239	CDD:275380	3/22 (14%)
		leucine-rich repeat	240..299	CDD:275380	20/112 (18%)
		LRR_8	299..356	CDD:290566	20/69 (29%)
		leucine-rich repeat	300..321	CDD:275380	7/22 (32%)
		leucine-rich repeat	322..345	CDD:275380	8/24 (33%)
		LRR_8	344..405	CDD:290566	20/60 (33%)
		leucine-rich repeat	346..365	CDD:275380	5/18 (28%)
		leucine-rich repeat	370..394	CDD:275380	11/23 (48%)
		leucine-rich repeat	395..420	CDD:275380	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453586
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840