DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32055 and ltl

DIOPT Version :9

Sequence 1:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	128/541 - (23%)
Similarity:	199/541 - (36%)	Gaps:	148/541 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 VTLGEKGLQDFKAL-----QKLN--------LTHAQLDELKSEQFPNPSEMINFD-----VSYND 133
            |.|..:.|:.|.|:     .|||        :||:|||:|:...|.:    :||:     :.:|.
  Fly    36 VELSCEKLESFNAVVDSLANKLNADTNIDLKITHSQLDDLEMRSFTD----MNFNLYKLRMQWNS 96

  Fly   134 ILAITTKLMSGFGNLVYANFSENLIAVIEPNAFRHMKNLRFLDL------------------TTN 180
            :.::......|..|:.|.:..:|.:..|..:|..||.:|..||:                  .||
  Fly    97 LKSLPEVPFRGLSNVTYLSIGDNDLDEIPKHALSHMPSLLTLDIGRCKIRAVQQEDFRGIQRVTN 161

  Fly   181 Y------------------------------------------------QENIT-----LGENAN 192
            .                                                ..|||     |.:...
  Fly   162 LILVSNIITRLDRGSFPKSLLILHLGRNQLESLNGSLHDLHNLESLFINANNITSLDDELPDGGQ 226

  Fly   193 LRFLSISNNNLRDFQWCHLRVLPKLEELHLHSNWLEHLDMGIFYALPNLRVLNVSNNNLFEIKRT 257
            ||.|...||.|.... .::..:..||.:|:|.|.|...|..:..|: ||..:...||.|
  Fly   227 LRLLMAHNNRLERLP-ANMAGMHSLETVHIHCNQLRSFDRVLRNAV-NLSEVMADNNEL------ 283

  Fly   258 LFMAPGEIA---PLELLDYSSNIVKVLDDSVFCRLKKLRTLNLWLNQINRIHPRAFLGLSSLQTL 319
            .::|..|.|   .:|.|....|.:|.|:.|:. .:.||:..|...|.|.........||.||:||
  Fly   284 EYLAQDEFASCSKVETLQMGCNHIKSLNSSLL-PILKLKNANFSFNDIEEFSMAELHGLRSLKTL 347

  Fly   320 HLQGNKIS-ILPDDVFANLTALEKLDLSKNNIQKLG-----------LRVFGERI---------- 362
            .|..|:|. :|||........|..|||..|.|..|.           |.:.|.|:
  Fly   348 QLSSNRIQRLLPDPRGVQELMLVNLDLDNNRIDSLNGALAGLGNLRILNLAGNRLEHLQVGDFDG 412

  Fly   363 LRKLIYLDLSNNYIADLHPLALSSMPFIKELRLRRNRLVSLDLRMFAPLRQLQLLTINENRLEEI 427
            :.:|..|||:.|.:|:|.||.::.:|.:|.|::..|.:..|: :.|..|..|....:..|::..|
  Fly   413 MIRLDILDLTGNQLAELKPLEMTLLPSLKILKVAYNNITKLE-QDFKGLPVLCQANLTNNQISTI 476

  Fly   428 DGEILDTLDRLNHLELNNNRLTFLPDLKSSQNLLQLRNITLEGNPWQC-LCLDEITSWLNGRHVS 491
            ..|::......||                  |:.....|.|:.||..| :.|:|:.. |.....:
  Fly   477 SSELVTNTRCKNH------------------NVPGKLEIHLDDNPIMCDVGLNELCR-LMAVQEA 522

  Fly   492 YARPSSAYFSGRKPLCVVTPM 512
            ..|..|..|...:.:|.|.||
  Fly   523 RIRGRSQCFENDQEVCTVLPM 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380	4/11 (36%)
		leucine-rich repeat	100..123	CDD:275380	10/35 (29%)
		LRR_8	128..180	CDD:290566	12/74 (16%)
		leucine-rich repeat	128..147	CDD:275380	2/23 (9%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		leucine-rich repeat	172..192	CDD:275380	9/90 (10%)
		LRR_RI	<187..400	CDD:238064	69/237 (29%)
		LRR_8	192..251	CDD:290566	18/58 (31%)
		leucine-rich repeat	193..216	CDD:275380	6/22 (27%)
		leucine-rich repeat	217..240	CDD:275380	8/22 (36%)
		leucine-rich repeat	241..267	CDD:275380	7/28 (25%)
		leucine-rich repeat	268..291	CDD:275380	6/22 (27%)
		LRR_8	290..350	CDD:290566	22/60 (37%)
		leucine-rich repeat	292..315	CDD:275380	6/22 (27%)
		leucine-rich repeat	316..339	CDD:275380	9/23 (39%)
		LRR_8	340..400	CDD:290566	23/80 (29%)
		leucine-rich repeat	340..365	CDD:275380	10/45 (22%)
		leucine-rich repeat	366..389	CDD:275380	9/22 (41%)
		leucine-rich repeat	390..413	CDD:275380	6/22 (27%)
		LRR_8	391..448	CDD:290566	12/56 (21%)
		leucine-rich repeat	414..437	CDD:275380	4/22 (18%)
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380	8/24 (33%)
		LRR_8	86..145	CDD:290566	12/58 (21%)
		leucine-rich repeat	87..110	CDD:275380	2/22 (9%)
		leucine-rich repeat	111..134	CDD:275380	6/22 (27%)
		leucine-rich repeat	135..158	CDD:275380	3/22 (14%)
		LRR_8	158..214	CDD:290566	2/55 (4%)
		leucine-rich repeat	159..180	CDD:275380	2/20 (10%)
		leucine-rich repeat	181..203	CDD:275380	0/21 (0%)
		leucine-rich repeat	204..226	CDD:275380	4/21 (19%)
		LRR_RI	226..451	CDD:238064	68/233 (29%)
		leucine-rich repeat	227..249	CDD:275380	6/22 (27%)
		leucine-rich repeat	250..272	CDD:275380	8/22 (36%)
		leucine-rich repeat	273..296	CDD:275380	7/28 (25%)
		leucine-rich repeat	297..315	CDD:275380	6/17 (35%)
		LRR_8	319..402	CDD:290566	26/82 (32%)
		leucine-rich repeat	320..335	CDD:275378	4/14 (29%)
		leucine-rich repeat	344..366	CDD:275380	9/21 (43%)
		leucine-rich repeat	367..391	CDD:275380	7/23 (30%)
		LRR_8	369..426	CDD:290566	15/56 (27%)
		leucine-rich repeat	392..415	CDD:275380	3/22 (14%)
		leucine-rich repeat	416..439	CDD:275380	9/22 (41%)
		LRR_8	438..>479	CDD:290566	10/41 (24%)
		leucine-rich repeat	440..462	CDD:275380	6/22 (27%)
		leucine-rich repeat	463..483	CDD:275380	4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453610
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940