DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32055 and igfals

DIOPT Version :9

Sequence 1:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	XP_002940278.2	Gene:	igfals / 100489984	XenbaseID:	XB-GENE-1008441	Length:	601	Species:	Xenopus tropicalis

Alignment Length:	425	Identity:	129/425 - (30%)
Similarity:	204/425 - (48%)	Gaps:	45/425 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 IERAEDGELPGLSTLLQLDLSESGGVTLGEKGLQDFKALQKLNLTHAQLDELKSEQFPNPSEMIN 126
            :.:.|||...|||.|..|:|..:..|.|.:....|...|::|.|...:|..|:...|.:..|:..
Frog   151 LTKIEDGLFSGLSNLWYLNLGWNLLVVLPDMVFHDLLNLRELVLAGNRLVYLQPSLFLSLGELKE 215

  Fly   127 FDVSYNDILAITTKLMSGFGNLVYANFSENLIAVIEPNAFRHMKNLRFLDLTTN-----YQENIT 186
            .|:|.|.:..|...:.:..........:.|.|:.:.|.||..|||||:|||:.|     |::  |
Frog   216 LDLSGNSLKGIKANVFTRQQKTHKLYLNHNHISTVAPRAFSGMKNLRWLDLSHNRLTALYED--T 278

  Fly   187 LGENANLRFLSISNNNLRDFQWCHLRVLPKLEELHLHSNWLEHLDMGIFYALPNLRVLNVSNNNL 251
            .....:|..|.:|||:|...:....:.|..|.||:|..|.::.|....|..|..|.:|::::||:
Frog   279 FFGLPSLNVLRLSNNSLTSLRPRIFKDLQFLVELNLGQNKIKILLERTFEGLAQLELLSLNHNNV 343

  Fly   252 FEIKRTLFMAPGEIAPLELLDYSSNIVKVLDDSVFCRLKKLRTLNLWLNQINRIHPRAFLGLSSL 316
            .||:...|:....:|.:.|   |.|.:|.|.:..|..|.||.:|::..:.::.|.|:.|.||||:
Frog   344 QEIRPGSFLGLLNVAVINL---SGNCLKSLAEHCFKGLGKLHSLHMESSCLSHIKPQMFAGLSSI 405

  Fly   317 QTLHLQGNKISILPDDVFANLTALEKLDLSKNNIQKLGLRVFGERILRKLIYLDLSNNYIADLHP 381
            :.|.||.|:|..:.|..|.:|..|.:|||..|.:..|..|.|..  |:.|.||.||:|.|..:.|
Frog   406 RRLFLQNNEIVAIEDHSFTDLHGLLELDLRSNKLTHLTTRSFTG--LKNLSYLLLSSNQILTISP 468

  Fly   382 LALSSMPFIKELRLRRNRLVSLDLRMFAPLRQLQLLTINENRLEEIDGEILDTLDRLNHLELNNN 446
                                    .:|:|::|||.|.:::|:|:.:..:|...|..|.:|.|.||
Frog   469 ------------------------EVFSPVQQLQWLDLSDNQLKALTEDIFLPLSSLRYLSLKNN 509

  Fly   447 RLTFLPDLKSSQNLL----QLRNITLEGNPWQCLC 477
            .|..:     |.|.|    .::.:.|.||.|.|.|
Frog   510 CLKTI-----SVNFLIPPPTMQQLWLNGNQWDCGC 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380	6/22 (27%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		LRR_8	128..180	CDD:290566	17/51 (33%)
		leucine-rich repeat	128..147	CDD:275380	4/18 (22%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		leucine-rich repeat	172..192	CDD:275380	8/24 (33%)
		LRR_RI	<187..400	CDD:238064	65/212 (31%)
		LRR_8	192..251	CDD:290566	18/58 (31%)
		leucine-rich repeat	193..216	CDD:275380	7/22 (32%)
		leucine-rich repeat	217..240	CDD:275380	8/22 (36%)
		leucine-rich repeat	241..267	CDD:275380	7/25 (28%)
		leucine-rich repeat	268..291	CDD:275380	7/22 (32%)
		LRR_8	290..350	CDD:290566	23/59 (39%)
		leucine-rich repeat	292..315	CDD:275380	7/22 (32%)
		leucine-rich repeat	316..339	CDD:275380	8/22 (36%)
		LRR_8	340..400	CDD:290566	17/59 (29%)
		leucine-rich repeat	340..365	CDD:275380	9/24 (38%)
		leucine-rich repeat	366..389	CDD:275380	8/22 (36%)
		leucine-rich repeat	390..413	CDD:275380	2/22 (9%)
		LRR_8	391..448	CDD:290566	15/56 (27%)
		leucine-rich repeat	414..437	CDD:275380	7/22 (32%)
igfals	XP_002940278.2	leucine-rich repeat	69..92	CDD:275380
		PLN00113	71..>534	CDD:215061	125/418 (30%)
		leucine-rich repeat	93..116	CDD:275380
		leucine-rich repeat	117..140	CDD:275380
		leucine-rich repeat	141..164	CDD:275380	5/12 (42%)
		leucine-rich repeat	165..188	CDD:275380	6/22 (27%)
		leucine-rich repeat	189..212	CDD:275380	6/22 (27%)
		leucine-rich repeat	213..236	CDD:275380	4/22 (18%)
		leucine-rich repeat	237..260	CDD:275380	6/22 (27%)
		leucine-rich repeat	261..284	CDD:275380	8/24 (33%)
		leucine-rich repeat	285..308	CDD:275380	7/22 (32%)
		leucine-rich repeat	309..332	CDD:275380	8/22 (36%)
		leucine-rich repeat	333..354	CDD:275380	7/20 (35%)
		leucine-rich repeat	357..380	CDD:275380	8/25 (32%)
		leucine-rich repeat	381..404	CDD:275380	7/22 (32%)
		leucine-rich repeat	405..428	CDD:275380	8/22 (36%)
		leucine-rich repeat	429..450	CDD:275380	8/22 (36%)
		leucine-rich repeat	453..472	CDD:275380	8/42 (19%)
		leucine-rich repeat	477..500	CDD:275380	7/22 (32%)
		leucine-rich repeat	525..537	CDD:275378	4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	164	1.000	Inparanoid score	I4082
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D299282at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.970