DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6628 and CRISP1

DIOPT Version :9

Sequence 1:	NP_648386.1	Gene:	CG6628 / 39183	FlyBaseID:	FBgn0036072	Length:	277	Species:	Drosophila melanogaster
Sequence 2:	NP_001122.2	Gene:	CRISP1 / 167	HGNCID:	304	Length:	249	Species:	Homo sapiens

Alignment Length:	222	Identity:	47/222 - (21%)
Similarity:	78/222 - (35%)	Gaps:	73/222 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SLKKHIACKNKGELGKQCSPDAHLVNLTGLQDLILGEHNALRNVLASGKIINLPKPDRMATLQWH 103
            |:||..|.....:|         :.:|..:|:.|:..|||||..:       :|....|..:.|.
Human    20 SMKKKSARDQFNKL---------VTDLPNVQEEIVNIHNALRRRV-------VPPASNMLKMSWS 68

  Fly   104 SELADLATLNVKQCVLQHDSCHNTP---DFHNS--GQNLALVNITLLPEDGNHTDECLVKESIGG 163
            .|.|..|.:..|.|    |...:.|   ...|:  |:|:   ::|..|...:..        ||.
Human    69 EEAAQNARIFSKYC----DMTESNPLERRLPNTFCGENM---HMTSYPVSWSSV--------IGV 118

  Fly   164 WWNQSINITKEQLQRFPKGKLGDSIRNFAVMARDNNTH--------VGCAALRFEKPAGHPLFLL 220
            |:::|.:.           |.|:.......:..|:.|.        :|| |:...:..|.|.:|.
Human   119 WYSESTSF-----------KHGEWTTTDDDITTDHYTQIVWATSYLIGC-AIASCRQQGSPRYLY 171

  Fly   221 ACNYASNYVPDWPIYKEKAIGCQSGSD 247
            .|:|                 |..|:|
Human   172 VCHY-----------------CHEGND 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6628	NP_648386.1	SCP_euk	69..225	CDD:240180	37/168 (22%)
CRISP1	NP_001122.2	SCP_CRISP	39..177	CDD:240183	38/188 (20%)
CRISP1	NP_001122.2	Crisp	195..249	CDD:285731
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151267
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1528782at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750