DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr10 and IGSF9

DIOPT Version :9

Sequence 1:	NP_729591.1	Gene:	dpr10 / 39180	FlyBaseID:	FBgn0052057	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens

Alignment Length:	352	Identity:	70/352 - (19%)
Similarity:	111/352 - (31%)	Gaps:	122/352 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 NITSLVGKSAYLGCRVKHLGNK----TVAWIRHRDL--HILTVGTYT------YTTDQRFQTSYH 114
            ::....|:|..|||.:.....:    .:.|:|...|  ..:..|.|:      |....|.|...
Human    28 SVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGA- 91

  Fly   115 RDIDEWTLQIKWAQQRDAGVYECQISTQPVRSYSVNLNIVDLIDAETSDIMQQYYNDDAFYIAEN 179
                  :|||:..:..|.|.|||::.                       .:.|:..:|.|
Human    92 ------SLQIEGLRVEDQGWYECRVF-----------------------FLDQHIPEDDF----- 122

  Fly   180 RVYQSSNDEFAGMF--GPIQTVAVPTATILGGPDLYVDKGSTINLTCIIKFSPEPPTHIFWYHQD 242
                 :|..:..:.  .|.|....|.|.      |.|.:...:.|.|:.:.||.|  |:.|..:.
Human   123 -----ANGSWVHLTVNSPPQFQETPPAV------LEVQELEPVTLRCVARGSPLP--HVTWKLRG 174

  Fly   243 KVLSE-----ETSGGRLKFKTIKSEETKSILLIYDADLLHSGKYSCYPSNTEIASIRVHVLQ--- 299
            |.|.:     :...|.|:.:.::...              ||.|:|..|:||.::  .|..|
Human   175 KDLGQGQGQVQVQNGTLRIRRVERGS--------------SGVYTCQASSTEGSA--THATQLLV 223

  Fly   300 -GER----PEAMQTNAAPAAVALAC------------W------SCHFGQATQAVRVISTMVAAL 341
             |..    |....|..|...|:|||            |      ..|..:....||
Human   224 LGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVR--------- 279

  Fly   342 VLLEACSSLLLQSGGGGGC----PGGG 364
            :|::....||.......||    |..|
Human   280 ILVDGSLRLLATQPDDAGCYTCVPSNG 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr10	NP_729591.1	Ig	63..143	CDD:299845	21/91 (23%)
		IG_like	210..297	CDD:214653	20/91 (22%)
		IGc2	217..287	CDD:197706	15/74 (20%)
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	25/143 (17%)
		IG_like	28..110	CDD:214653	21/88 (24%)
		I-set	136..223	CDD:254352	25/110 (23%)
		Ig	154..220	CDD:143165	19/83 (23%)
		Ig_3	226..305	CDD:290638	17/87 (20%)
		IG_like	233..319	CDD:214653	17/83 (20%)
		Ig	341..404	CDD:299845
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810