DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr10 and robo4

DIOPT Version :9

Sequence 1:	NP_729591.1	Gene:	dpr10 / 39180	FlyBaseID:	FBgn0052057	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	XP_689255.3	Gene:	robo4 / 560765	ZFINID:	ZDB-GENE-020809-1	Length:	1134	Species:	Danio rerio

Alignment Length:	452	Identity:	86/452 - (19%)
Similarity:	143/452 - (31%)	Gaps:	136/452 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LWTALFC-CLTGL--AVCYQRQSVSNNNHNNAEAKP--THAPPSHYPHGH--KWNEPYFDLTMPR 61
            ||.|..| |...:  ..|...:.|:..:......:.  .|...||....|  |.:....::.:||
Zfish     8 LWVAWLCTCSKAVRQCACPPDEQVAQRSEGKGHLRHRLMHQRASHRDRAHRRKGSRLVSEINLPR 72

  Fly    62 ------NITSLVGKSAYLGCRVKHLGNKTVAWIRHRDLHILTVGTYTYTTDQRFQTSYHRDIDEW 120
                  ::...||..|.|.||.:.....|:.|:|:
Zfish    73 IVHHPSDVVVRVGSPATLSCRAEGNPEPTIQWLRN------------------------------ 107

  Fly   121 TLQIKWAQQRDAGVYECQISTQPVRSYSVNLNIVDLIDAETSDIMQQYYNDDAFY--IAENRVYQ 183
                  .|..|....:.|  :||:.....:|....::......      :.:|.|  ||.|.:..
Zfish   108 ------GQPLDTDKMDAQ--SQPIVLPDGSLFFFSVVPGRKGQ------SHEAVYACIAHNSIGN 158

  Fly   184 SSNDEFAGMFGPIQTVAVPTATILGGPDLYVDKGSTINLTCIIKFSP---EPPTHIFWYHQDKVL 245
            :::..     ..:...|:.....:...|:.|..|....:.|    ||   .|..::.| .:|.:|
Zfish   159 ATSRN-----ASLHIAALREDFRVQPSDVEVAIGEMATINC----SPPVGHPEPNVTW-RKDGIL 213

  Fly   246 SEETSGGRLKFKTIKSEETKSILLIYDADLLHSGKYSCYPSN----TEIASIRVHVLQG----ER 302
            ...::.        ...|.|..|:|..|....||.|||..||    .|..:.|:.||..    .:
Zfish   214 INSSNE--------HYTELKGKLIIAPAQKNDSGVYSCIASNMIGVRESRAARLSVLAKPVLLRK 270

  Fly   303 PEAMQTNAAPAAVALAC-----------WS--------------------CHFGQATQAVRVIST 336
            ||.:......:| ...|           ||                    .|:..|....|...|
Zfish   271 PEDVSVQLGESA-QFFCEADGDPMPSIEWSREQGPLPNGRYLINPDHSLQIHYVTAQDMGRYSCT 334

  Fly   337 MVAALVLLEACSSLLLQSGGGGGCPGGGSPAGGMPTRVREIREK--PLTNSLLDPKIPSTTS 396
            :...|.:..|.:.||::..||              ||:|::.::  .|..||.:..:.||.|
Zfish   335 VENKLGVSVASAQLLVEDAGG--------------TRLRDLHKELSALRVSLENVTVMSTAS 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr10	NP_729591.1	Ig	63..143	CDD:299845	12/79 (15%)
		IG_like	210..297	CDD:214653	24/93 (26%)
		IGc2	217..287	CDD:197706	18/72 (25%)
robo4	XP_689255.3	Ig1_Robo	70..169	CDD:143317	22/147 (15%)
		I-set	71..168	CDD:254352	22/145 (15%)
		I-set	175..261	CDD:254352	24/98 (24%)
		Ig2_Robo	177..261	CDD:143201	24/96 (25%)
		I-set	265..350	CDD:254352	13/85 (15%)
		Ig	282..350	CDD:299845	11/68 (16%)
		FN3	373..448	CDD:214495	3/10 (30%)
		FN3	472..560	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900