DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr10 and Sdk2

DIOPT Version :9

Sequence 1:	NP_729591.1	Gene:	dpr10 / 39180	FlyBaseID:	FBgn0052057	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	XP_006247755.1	Gene:	Sdk2 / 360652	RGDID:	1310397	Length:	2175	Species:	Rattus norvegicus

Alignment Length:	382	Identity:	77/382 - (20%)
Similarity:	135/382 - (35%)	Gaps:	99/382 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PYFDLTMPRNITSLVGKSAYLGCRVKHLGNKTVAWIRHRDLHILTVGTYTYTTDQRFQTSYHRDI 117
            |.|.....|:||:.:.|...:.||.|.:...::.|  ::|..::.||..|     ||:
  Rat   311 PQFVREPERHITAEMEKVVDIPCRAKGVPPPSITW--YKDAALVEVGKLT-----RFK------- 361

  Fly   118 DEWTLQIKWAQQRDAGVYECQISTQPVRSYSVNLNIVDLIDAETSDIMQQYYNDDAFYIAENRVY 182
                      |:.|.|                 |.|..|:..:|.  |.|.:..:|...|:...|
  Rat   362 ----------QRSDGG-----------------LQISGLLPDDTG--MVQCFAHNAAGEAQTSTY 397

  Fly   183 QSSNDEFAGMFGPIQTVAVPTATILGGP-DLYVDKGSTINLTCIIKFSPEPPTHIFWYHQDKVLS 246
            .:           :.::|   ..|..|| |..|..|.::.|.|....:|.|.  |.|...:::|
  Rat   398 LA-----------VTSIA---PNITRGPLDSTVIDGMSVVLACETSGAPRPA--ITWQKGERIL- 445

  Fly   247 EETSGGRLKFKTIKSEETKSILLIYDADLLHSGKYSCYPSNTE---------IASIRVHVLQGER 302
               :.|.::.......|:.| |||....:..:|.|:|..:|:.         :...|..:   .:
  Rat   446 ---ASGSVQLPRFTLLESGS-LLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRI---TK 503

  Fly   303 PEAMQTNAAPAAVALACWSCHFGQATQAVRVISTMVAALVLLEACSSLLLQSGGG-------GGC 360
            |...|:.......::.|...|..:.|  ||.:.....|.:.:|....:.|...|.       .|.
  Rat   504 PPQDQSVIKGTQASMVCGVTHDPRVT--VRYVWEKDGATLAVETNPRIRLDRNGSLHISQTWSGD 566

  Fly   361 PG---------GGSPAGGMPTRVREIREKP----LTNSLLDPKIPSTTSAERVNNGS 404
            .|         ||:.:.....|||::...|    .|.|.::.:..:.|.|:..:..|
  Rat   567 IGTYTCRVLSAGGNDSRNAHLRVRQLPHAPEHPVATLSTMERRAINLTWAKPFDGNS 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr10	NP_729591.1	Ig	63..143	CDD:299845	16/79 (20%)
		IG_like	210..297	CDD:214653	22/96 (23%)
		IGc2	217..287	CDD:197706	17/69 (25%)
Sdk2	XP_006247755.1	IG_like	43..112	CDD:214653
		IGc2	43..101	CDD:197706
		IG_like	123..206	CDD:214653
		Ig	135..191	CDD:299845
		IG_like	225..307	CDD:214653
		IGc2	236..289	CDD:197706
		I-set	311..400	CDD:254352	28/142 (20%)
		Ig	329..397	CDD:143165	21/110 (19%)
		I-set	405..495	CDD:254352	23/96 (24%)
		Ig	419..495	CDD:299845	18/82 (22%)
		Ig	505..589	CDD:299845	14/85 (16%)
		IG_like	505..589	CDD:214653	14/85 (16%)
		FN3	593..684	CDD:238020	6/31 (19%)
		FN3	696..789	CDD:238020
		FN3	797..893	CDD:238020
		FN3	898..986	CDD:238020
		FN3	996..1090	CDD:238020
		FN3	1102..1197	CDD:238020
		FN3	1204..1293	CDD:238020
		FN3	1304..1397	CDD:238020
		FN3	1403..1487	CDD:238020
		FN3	1506..1619	CDD:238020
		FN3	1629..1722	CDD:238020
		FN3	1727..1808	CDD:238020
		FN3	1840..1919	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810