DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr10 and Lrit1

DIOPT Version :9

Sequence 1:	NP_729591.1	Gene:	dpr10 / 39180	FlyBaseID:	FBgn0052057	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_647547.2	Gene:	Lrit1 / 246214	RGDID:	628607	Length:	623	Species:	Rattus norvegicus

Alignment Length:	391	Identity:	76/391 - (19%)
Similarity:	128/391 - (32%)	Gaps:	106/391 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LTMPRNITSLVGKSAYLGC-RVKHL---GNK--TVAWIRHRD---------------------LH 94
            |.:|.|..|.:......|. |::.|   ||.  |..|...:|                     :|
  Rat    88 LWLPYNALSELSTLMLRGLRRLRELRLPGNHLVTFPWAALKDTPQLQLLDLQANRLSTLPPEAVH 152

  Fly    95 ILTVGTYTYTTDQRFQTSYHRDIDEWT------------LQIKWAQQRDAGVYECQISTQPVRSY 147
            .|...|:...::.:........:|.|.            .::....|.:..|.:|::
  Rat   153 FLENLTFLDLSNNQLMRLPEELLDTWAHLKTGPYLSSRRTRLVLGLQDNPWVCDCRL-------- 209

  Fly   148 SVNLNIVDLIDAETSDIMQQYYNDDAFYIAENRVYQSSNDEFAGM-FGPIQTVAVPTATILGGPD 211
               .::|.|:|...|:::          ..|.|:...|....||: |..::.....:..:..|..
  Rat   210 ---YDLVHLLDGWASNLI----------FIEARLRCGSPRSLAGVAFSQLELRKCQSPELRPGVT 261

  Fly   212 LYVDK-GSTINLTCIIKFSPEPPTHIFWYHQDKVLSEETSGGRLKFKTIKSEETK-----SILLI 270
            ..:.. |||:.|.|.....|.|.           :|...:.||....|:..|.:.     ::|.:
  Rat   262 SIISPLGSTVLLRCGATGIPGPE-----------MSWRRANGRPLNGTVHQEVSSDGSSWTLLDL 315

  Fly   271 YDADLLHSGKYSCYPSNTEIASIRVHVLQGERPEAMQTNAAPAAVALACWSCHFGQATQAVRVIS 335
            ....|..||.|.|...|...||..:..|....|   ||:.....:..|.|: ..|:..:|....:
  Rat   316 PVVSLFDSGDYICQAKNFLGASETLISLIVTEP---QTSTEYTGIPGALWA-RTGEGAEAAAYNN 376

  Fly   336 TMVAALVLLEACSSLLLQSGGGGGCPGGGSPAGGMPTR--VREIREK-PLTNSLLDPKIPSTTSA 397
            .:||..|                  |....|. .:.|:  |..|:|: ||.|..:|  :|...|.
  Rat   377 KLVARHV------------------PHVPEPV-ALATKPSVPSIKEELPLQNFQMD--VPGEFSR 420

  Fly   398 E 398
            |
  Rat   421 E 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr10	NP_729591.1	Ig	63..143	CDD:299845	17/118 (14%)
		IG_like	210..297	CDD:214653	21/92 (23%)
		IGc2	217..287	CDD:197706	18/74 (24%)
Lrit1	NP_647547.2	LRRNT	23..61	CDD:214470
		LRR 1	60..81
		LRR_8	63..143	CDD:290566	12/54 (22%)
		leucine-rich repeat	64..84	CDD:275378
		LRR 2	84..105		4/16 (25%)
		leucine-rich repeat	85..132	CDD:275378	12/43 (28%)
		LRR 3	108..128		6/19 (32%)
		LRR_8	131..>176	CDD:290566	3/44 (7%)
		LRR_4	131..172	CDD:289563	3/40 (8%)
		LRR 4	132..153		0/20 (0%)
		leucine-rich repeat	133..156	CDD:275378	2/22 (9%)
		LRR 5	156..177		1/20 (5%)
		leucine-rich repeat	157..180	CDD:275378	3/22 (14%)
		leucine-rich repeat	181..205	CDD:275378	1/23 (4%)
		TPKR_C2	201..>240	CDD:301599	9/59 (15%)
		Ig	257..345	CDD:299845	23/98 (23%)
		IG_like	267..345	CDD:214653	22/88 (25%)
		FN3	431..501	CDD:214495
		LRR 6	525..548
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900