DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr10 and SDK1

DIOPT Version :9

Sequence 1:NP_729591.1 Gene:dpr10 / 39180 FlyBaseID:FBgn0052057 Length:408 Species:Drosophila melanogaster
Sequence 2:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens


Alignment Length:382 Identity:76/382 - (19%)
Similarity:131/382 - (34%) Gaps:134/382 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 PYFDLTMPRNITSLVGKSAYLGCRVKHLGNKTVAWIRHRDLHILTVGTYTYTTDQRFQTSYHRDI 117
            |||.......|::.|.::..:||:...:...|:.|  ::|...::          |.|...::.:
Human   386 PYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQW--YKDAISIS----------RLQNPRYKVL 438

  Fly   118 DEWTLQIKWAQQRDAGVYECQISTQPVRSYSVNLNIVDLIDAETSDIMQQYYNDDAFYIAENRVY 182
            ....|:|:..:..|:|:::|..|.                  |..:|....|.|..         
Human   439 ASGGLRIQKLRPEDSGIFQCFASN------------------EGGEIQTHTYLDVT--------- 476

  Fly   183 QSSNDEFAGMF--GPIQTVAVPTATILGGPDLYVDKGSTINLTCIIKFSPEPPTHIFWYHQDKVL 245
                 ..|.:|  .|:.|.              |..|.|..|.|.:..:|:|.  |.|..::.:|
Human   477 -----NIAPVFTQRPVDTT--------------VTDGMTAILRCEVSGAPKPA--ITWKRENHIL 520

  Fly   246 SEETSGG-RL-KFKTIKSEETK-SILLIYDADLLHSGKYSCYPSNTEIASIRVHVLQGERPEAMQ 307
            :   ||. |: :|..::|...: :.:.|.||     |.|:||.:|||                  
Human   521 A---SGSVRIPRFMLLESGGLQIAPVFIQDA-----GNYTCYAANTE------------------ 559

  Fly   308 TNAAPAAVALACW--------------------SCHFGQATQAVRV------------ISTMVAA 340
             .:..|:..|..|                    :.|.| ||...||            ::....:
Human   560 -GSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCG-ATHDPRVSLRYVWKKDNVALTPSSTS 622

  Fly   341 LVLLEACSSLLLQ---SG--GGGGC---PGGGSPAGGMPTRVREIREKPLTNSLLDP 389
            .:::|...|||:.   ||  |...|   ..||:.:......|.|:...| .|.|:.|
Human   623 RIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSP-QNLLVSP 678

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr10NP_729591.1 Ig 63..143 CDD:299845 15/79 (19%)
IG_like 210..297 CDD:214653 25/89 (28%)
IGc2 217..287 CDD:197706 21/72 (29%)
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
I-set 104..188 CDD:254352
Ig 122..176 CDD:143165
Ig 219..265 CDD:299845
IGc2 312..364 CDD:197706
I-set 386..475 CDD:254352 21/118 (18%)
Ig 404..472 CDD:143165 15/97 (15%)
I-set 480..570 CDD:254352 30/132 (23%)
Ig 494..570 CDD:299845 26/104 (25%)
I-set 575..664 CDD:254352 16/89 (18%)
Ig 580..664 CDD:299845 16/84 (19%)
FN3 668..759 CDD:238020 4/12 (33%)
fn3 771..857 CDD:278470
FN3 872..967 CDD:238020
FN3 972..1054 CDD:238020
FN3 1070..1166 CDD:238020
FN3 1176..1271 CDD:238020
fn3 1279..1365 CDD:278470
FN3 1378..1471 CDD:238020
FN3 1477..1572 CDD:238020
FN3 1580..1694 CDD:238020
FN3 1704..1797 CDD:238020
FN3 1802..1883 CDD:238020
FN3 1903..1996 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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