DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr10 and Ncam1

DIOPT Version :9

Sequence 1:	NP_729591.1	Gene:	dpr10 / 39180	FlyBaseID:	FBgn0052057	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	XP_006510118.1	Gene:	Ncam1 / 17967	MGIID:	97281	Length:	1162	Species:	Mus musculus

Alignment Length:	451	Identity:	86/451 - (19%)
Similarity:	148/451 - (32%)	Gaps:	165/451 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GKSAYLGCRVKHLGNKTVAWIRHRDLHILTVGTYTYTTDQRF---QTSYHRDIDEWTLQIKWAQQ 129
            |:.|.:.|.|......|:.| :|:...::      ...|.||   ..:|        |||:..::
Mouse   132 GEDAVIVCDVVSSLPPTIIW-KHKGRDVI------LKKDVRFIVLSNNY--------LQIRGIKK 181

  Fly   130 RDAGVYECQ------------------------ISTQPVRSYSVNL--NIVDLIDAE-------- 160
            .|.|.|.|:                        .:.|.:.:.:.||  ::..:.||:
Mouse   182 TDEGTYRCEGRILARGEINFKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMS 246

  Fly   161 -TSD------------------------IMQQYYNDDAFY--IAENRVYQSSNDEFAGMFGPIQT 198
             |.|                        |.....||:|.|  ||||:    :.::.|.:.  ::.
Mouse   247 WTKDGEPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENK----AGEQDASIH--LKV 305

  Fly   199 VAVPTATILGGPDLYVDKGST------INLTCIIKFSPEPPTHIFWYHQDKVLS----------- 246
            .|.|..|       ||:..:.      :.|||  :.|.:|...|.|....:.:|
Mouse   306 FAKPKIT-------YVENQTAMELEEQVTLTC--EASGDPIPSITWRTSTRNISSEEKASWTRPE 361

  Fly   247 -EETSGGRLKFKTIKSEETKSILLIYDADLLHSGKYSCYPSNTEIASIRVHVLQGERPEAMQTNA 310
             :||..|.:   .::|....|.|.:.......:|:|.|..|||        :.|..:...::...
Mouse   362 KQETLDGHM---VVRSHARVSSLTLKSIQYTDAGEYICTASNT--------IGQDSQSMYLEVQY 415

  Fly   311 AP---AAVALACW-------SCH---FGQAT---------------QAVRVISTMVAALVLLEAC 347
            ||   ..||:..|       :|.   :..||               ..:::.:|..|:.:.:...
Mouse   416 APKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPD 480

  Fly   348 SSLLLQSGGGGGCPGGGSPAGGMPTRVREIREKPLTNSLLDPKIPSTTSAERVNNGSRNAR 408
            |.   ...|...|           |.|..|.::.|...|:....||:.|.:||...|..|:
Mouse   481 SE---NDFGNYNC-----------TAVNRIGQESLEFILVQADTPSSPSIDRVEPYSSTAQ 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr10	NP_729591.1	Ig	63..143	CDD:299845	18/101 (18%)
		IG_like	210..297	CDD:214653	22/104 (21%)
		IGc2	217..287	CDD:197706	17/87 (20%)
Ncam1	XP_006510118.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652	17/72 (24%)
		Ig3_NCAM-1_like	211..308	CDD:143207	17/102 (17%)
		Ig_NCAM-1	307..413	CDD:143277	26/125 (21%)
		Ig_3	417..494	CDD:372822	13/90 (14%)
		FN3	509..606	CDD:238020	7/19 (37%)
		fn3	649..731	CDD:365830
		PHA03247	<905..1140	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900