DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr10 and Dscam

DIOPT Version :9

Sequence 1:	NP_729591.1	Gene:	dpr10 / 39180	FlyBaseID:	FBgn0052057	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus

Alignment Length:	237	Identity:	47/237 - (19%)
Similarity:	86/237 - (36%)	Gaps:	73/237 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 RNITSLVGKSAYLGCRVKHLGNKTVAWIRHRDLHILTVGTYTYTTDQRFQTSYHRDI---DEWTL 122
            :|||::.|:..|:.|||......::.|.::.:|....                ||.:   :..||
Mouse   511 KNITAIAGRDTYIHCRVIGYPYYSIKWYKNANLLPFN----------------HRQVAFENNGTL 559

  Fly   123 QIKWAQQR-DAGVYECQISTQPVRSYSVNLNIVDLIDAETSDIMQQYYNDDAFYIAENRVYQSSN 186
            ::...|:. |.|.|.|.:..||..|.|.::::.    .:....:|.:
Mouse   560 KLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVT----VKVPPFIQPF------------------ 602

  Fly   187 DEFAGMFGPIQTVAVPTATILGGPDLYVDKGSTINLTCIIKFSPEPPTHIFWYHQDKVLSEETSG 251
             ||            |..:|          |..:.:.|:: .|.:.|..|.|....:.:.....
Mouse   603 -EF------------PRFSI----------GQRVFIPCVV-VSGDLPITITWQKDGRPIPASLG- 642

  Fly   252 GRLKFKTIKSEETKSILLIYDADLLHSGKYSCYPSNTEIASI 293
                 .||.:.:..|.|.|.:..|:|:|.|:|...| |.|::
Mouse   643 -----VTIDNIDFTSSLRISNLSLMHNGNYTCIARN-EAAAV 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr10	NP_729591.1	Ig	63..143	CDD:299845	18/83 (22%)
		IG_like	210..297	CDD:214653	19/84 (23%)
		IGc2	217..287	CDD:197706	16/69 (23%)
Dscam	XP_006522949.1	Ig	15..115	CDD:386229
		IGc2	239..300	CDD:197706
		IG	320..400	CDD:214652
		Ig_3	410..488	CDD:372822
		IGc2	518..575	CDD:197706	15/72 (21%)
		Ig	596..686	CDD:386229	24/132 (18%)
		Ig_DSCAM	707..784	CDD:143211
		Ig	802..889	CDD:386229
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig_3	1301..1363	CDD:372822
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900