DRSC/TRiP Functional Genomics Resources

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Protein Alignment LAMC2 and LanA

DIOPT Version :9

Sequence 1:NP_005553.2 Gene:LAMC2 / 3918 HGNCID:6493 Length:1193 Species:Homo sapiens
Sequence 2:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster


Alignment Length:1453 Identity:345/1453 - (23%)
Similarity:554/1453 - (38%) Gaps:450/1453 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    28 CDCN---GKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCNCNSK 89
            |:|:   ..|.:|      |...|   :| .|..|.....|..|::.:|...:   |.||.|.: 
  Fly  1375 CNCDYAGSTSFEC------HPFGG---QC-QCKPNVIERTCGACRSRYYGFPD---CKPCKCPN- 1425

Human    90 GSLSARCD-NSGRCSCKPGVTGARCDRCLP---GFHMLTDAGCTQDQRLLDSKCDCDPAGIA--- 147
               ||.|: .:|.|.|.|.|.|..|::|.|   |||.:  .||        .:|.|:|.|||   
  Fly  1426 ---SAMCEPTTGECMCPPNVIGDLCEKCAPNTYGFHQV--IGC--------EECACNPMGIANGN 1477

Human   148 -------GPCDA-----------------------------------------GRCVCKPAVTGE 164
                   |.|:.                                         |.|.||..|.|.
  Fly  1478 SQCDLFNGTCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGTELEVCDKIDGACFCKKNVVGR 1542

Human   165 RCDRCRSGYYNLDGGNPEGCTQCFCYGHSASCRSSAEYSVHKI---------TSTFHQD---VDG 217
            .||:|..|.|||...||:|||.|||:|.::.| .||...|:.:         |..||::   .|.
  Fly  1543 DCDQCVDGTYNLQESNPDGCTTCFCFGKTSRC-DSAYLRVYNVSLLKHVSITTPEFHEESIKFDM 1606

Human   218 WKA----VQRNGSPAKLQWSQRHQDVFSSAQRLDPVYFVAPAKFLGNQQ---VSYGQSLSFDYRV 275
            |..    :..|.:..|..::.|.    .:.:|  |.|| ....:|.||.   .:||..|::....
  Fly  1607 WPVPADEILLNETTLKADFTLRE----VNDER--PAYF-GVLDYLLNQNNHISAYGGDLAYTLHF 1664

Human   276 DRG--GRHPSAHDVIL--EGAGLRITAPLMPLGKTLPCGLTKTYTFRLNEHPSN----NWSPQLS 332
            ..|  |::..|.||||  |...|..|:...|       ...:.:|.|:|...||    :..| :|
  Fly  1665 TSGFDGKYIVAPDVILFSEHNALVHTSYEQP-------SRNEPFTNRVNIVESNFQTISGKP-VS 1721

Human   333 YFEYRRLLRNLTALRIRATYGEYS-TGYIDNVTLISARPVSGAPAPW----VEQCICPVGYKGQF 392
            ..::..:||:|..:.|||.|.|.: ..::.:|.|..|...:.....:    ||:|.||.||.|..
  Fly  1722 RADFMMVLRDLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYSGHS 1786

Human   393 CQDCASGYKRDSARLGPF-GTCIPCNCQG-GGACDPDTG---DCYSGDENPDIECADCPIGFYND 452
            |:|||.||.||.:  ||: |.||||.|.| ...||..||   .|..|.|..  .|..|..|:|.:
  Fly  1787 CEDCAPGYYRDPS--GPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGD--HCERCVSGYYGN 1847

Human   453 PHD--PRSCKPCPC-----HNGF--SCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDP--FG 506
            ..:  |..|..|.|     .|.|  ||.:....:::.| .|.||.||.|||.||:|::|:|  .|
  Fly  1848 ATNGTPGDCMICACPLPFDSNNFATSCEISESGDQIHC-ECKPGYTGPRCESCANGFYGEPESIG 1911

Human   507 EHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCR 571
            :     .|:||:|:.|::|...|:||..||.||:|::||.|..|:.|..|::||.:   ....|:
  Fly  1912 Q-----VCKPCECSGNINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAI---KLKNCQ 1968

Human   572 ACNCNPMGSEP--------------------------------VGCRS---------------DG 589
            :|:|:.:|::.                                ||||:               .|
  Fly  1969 SCDCDDLGTQTCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDCGAASNSTQCDPHTG 2033

Human   590 TCVCKPGFGGPNCEHGAFS-----------------------------------------CPACY 613
            .|.||.|..|..|:..|..                                         |.||.
  Fly  2034 HCACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGDRCDACP 2098

Human   614 NQVKIQMDQFMQQLQRM-EALISKAQGGDGVVPDTELEGRMQ-QAEQALQDILRDAQISEGASRS 676
            |:..:..|:..|:.... .||:             ::..||: |.:..|:|.             
  Fly  2099 NRWVLIKDEGCQECNNCHHALL-------------DVTDRMRYQIDSVLEDF------------- 2137

Human   677 LGLQLAKVRSQENSYQSRL-DDLKMTVERV----------RALGSQYQNRVRDTHRLITQMQLSL 730
            ..:.||...||:.:|..:| |:|:..|:.:          :...|:.::   |......|:..:|
  Fly  2138 NSVTLAFFTSQKLNYYDQLADELEPKVKLLDPNSVDLSPSKKANSELES---DAKSYAKQVNQTL 2199

Human   731 A-------ESEASLGNTNIPASDHYVGPNGFKSLAQEATRLAESHVESASNMEQLTRETEDYSKQ 788
            |       .|..:|||..: |.|             ||.:.|:...|:.:::|.|::..|     
  Fly  2200 ANAFDIRERSSTTLGNITV-AYD-------------EAVKSADQAKEAIASVEALSKNLE----- 2245

Human   789 ALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTKSLAQQLTREATQAEIEA---DRSYQHSLR 850
                         .:.|...|.|:.|            ||.:..:.....||.   ::..:.:.:
  Fly  2246 -------------AAASTKIDAALEQ------------AQHILGQINGTSIELTPNEQVLEKARK 2285

Human   851 LLDSVSRLQGVSDQSFQVEEAKRIKQKADSLSSLVTRHMDEFKRTQKNLGNWKEEA--------- 906
            |.:.|:.|            ...||.:..||::| ...:.||....::|.||.|.:         
  Fly  2286 LYEEVNTL------------VLPIKAQNKSLNAL-KNDIGEFSDHLEDLFNWSEASQAKSADVER 2337

Human   907 -----QQLLQNGKSGREKSDQLLSRANLAKSRAQEALSMGNATFYEVESILKNLRE-------FD 959
                 |:...|.|.......:|.:..|:  ..|...|..|:.|..::...|.|||:       |:
  Fly  2338 RNVANQKAFDNSKFDTVSEQKLQAEKNI--KDAGNFLINGDLTLNQINQKLDNLRDALNELNSFN 2400

Human   960 LQVD---------NRKAEA--EEAMKRLSYISQKVSDA----SDKTQQAERALGSAAADAQRAKN 1009
            ..||         :::|:|  ::|.::.:.::.|..|.    :|.|..||.|:.:|.     |.:
  Fly  2401 KNVDEELPVREDQHKEADALTDQAEQKAAELAIKAQDLAAQYTDMTASAEPAIKAAT-----AYS 2460

Human  1010 GAGEALEISSEIEQEIGSLNLEANVTADG----ALAMEKGLASL----KSEMREVEGELERKELE 1066
            |..||:|.:.::.|:..|....|....||    |...:.|...|    :..:::|:.:||.:   
  Fly  2461 GIVEAVEAAQKLSQDAISAAGNATDKTDGIEERAHLADTGSTDLLQRARQSLQKVQDDLEPR--- 2522

Human  1067 FDTNMDAVQMV-----ITEAQKVDTRA--------------KNAGVTIQDTLNTLDGLLHLMDQP 1112
            .:.:...||.:     .||.|..|...              ||:.....|.|..|..:|.:: :|
  Fly  2523 LNASAGKVQKISAVNNATEHQLKDINKLIDQLPAESQRDMWKNSNANASDALEILKNVLEIL-EP 2586

Human  1113 LSVD-----------EEGLVLLEQKLSRAKTQIN------SQLRPMMSELEERARQQRGHLHLLE 1160
            :||.           ...|.|..:.:|:|..|::      |:|..:..::||:..:.......|.
  Fly  2587 VSVQTPKELEKAHGINRDLDLTNKDVSQANKQLDDVEGSVSKLSELAEDIEEQQHRVGSQSRQLG 2651

Human  1161 TSIDGILADVKNLENIRDNLPPG 1183
            ..|:.:.|.|:....:.:::..|
  Fly  2652 QEIENLKAQVEAARQLANSIKVG 2674

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LAMC2NP_005553.2 EGF_Lam 28..78 CDD:238012 12/52 (23%)
EGF_Lam 83..127 CDD:238012 18/47 (38%)
Laminin_EGF 139..184 CDD:278482 23/95 (24%)
LamB 245..370 CDD:214597 39/136 (29%)
EGF_Lam 461..509 CDD:238012 21/56 (38%)
EGF_Lam 516..565 CDD:238012 21/48 (44%)
EGF_Lam 572..>604 CDD:238012 14/78 (18%)
Domain II and I 603..1193 135/725 (19%)
PspA_IM30 851..1058 CDD:281941 55/250 (22%)
SPEC 891..1111 CDD:295325 61/282 (22%)
LanANP_476617.1 LamNT 18..271 CDD:214532
EGF_Lam 272..>314 CDD:238012
EGF_Lam 332..389 CDD:238012
EGF_Lam 402..443 CDD:238012
EGF_Lam 448..491 CDD:238012
Laminin_EGF 495..543 CDD:278482
Laminin_EGF 541..589 CDD:278482
Laminin_EGF 587..634 CDD:278482
EGF_Lam 631..673 CDD:238012
Laminin_EGF 677..729 CDD:278482
Laminin_EGF 732..782 CDD:278482
EGF_Lam 785..828 CDD:238012
CBM6-CBM35-CBM36_like 831..966 CDD:271143
Laminin_EGF 1375..1423 CDD:278482 15/60 (25%)
EGF_Lam 1420..1457 CDD:238012 15/40 (38%)
Laminin_EGF 1466..1516 CDD:278482 8/49 (16%)
Laminin_EGF 1514..1562 CDD:278482 15/47 (32%)
LamB 1632..1760 CDD:214597 39/138 (28%)
Laminin_EGF <1775..1801 CDD:278482 14/27 (52%)
EGF_Lam 1808..1851 CDD:238012 15/44 (34%)
EGF_Lam 1859..1907 CDD:214543 19/48 (40%)
EGF_Lam 1916..1968 CDD:238012 21/54 (39%)
EGF_Lam 1969..2015 CDD:238012 5/45 (11%)
EGF_Lam 2016..>2054 CDD:238012 8/37 (22%)
EGF_Lam 2063..>2097 CDD:238012 1/33 (3%)
Laminin_I 2129..2385 CDD:283627 61/330 (18%)
Tar 2278..2662 CDD:223910 84/407 (21%)
Laminin_II 2566..2700 CDD:283628 21/110 (19%)
LamG 2674..2843 CDD:238058 1/1 (100%)
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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