DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32053 and HXT2

DIOPT Version :9

Sequence 1:	NP_729587.1	Gene:	CG32053 / 39178	FlyBaseID:	FBgn0052053	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_013724.1	Gene:	HXT2 / 855023	SGDID:	S000004613	Length:	541	Species:	Saccharomyces cerevisiae

Alignment Length:	563	Identity:	130/563 - (23%)
Similarity:	217/563 - (38%)	Gaps:	115/563 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QTERPSPDDGFHVVPIHSDAEQHIHRNSDRQRELILQNSQTSPCCNRDLRNQPQAN--AVGAAAL 64
            :.|..|.....|..||....|..         |..:|..  |...|.:|..:|.|.  .|....|
Yeast     8 RVESGSQQTSIHSTPIVQKLETD---------ESPIQTK--SEYTNAELPAKPIAAYWTVICLCL 61

  Fly    65 IFLTGGVHIAWSIGFDSS---------------------LSELEVTNHVQI----CWFIGAIIGA 104
            :...||....|..|..|.                     ||::.....|.|    |.|.|..:|.
Yeast    62 MIAFGGFVFGWDTGTISGFVNQTDFKRRFGQMKSDGTYYLSDVRTGLIVGIFNIGCAFGGLTLGR 126

  Fly   105 LLGGFFSRWFPYKTLMEFCSLITITGGIVMAVNRMD------LDALLAGRYMNGLANGLAIAPTL 163
             ||..:.|     .:...|.::....|||:.:...|      :..:::|..:.|:|   .::|||
Yeast   127 -LGDMYGR-----RIGLMCVVLVYIVGIVIQIASSDKWYQYFIGRIISGMGVGGIA---VLSPTL 182

  Fly   164 AMAGELSVFYKRGTTTSAAEQWPTTIGIFVQIVCSHSWDVQSDFTEEQFQGVLSGVLGSIAL-LL 227
              ..|.:..:.|||..| ..|...|:|||:....::.   ..|::......|..|:..:.|: ::
Yeast   183 --ISETAPKHIRGTCVS-FYQLMITLGIFLGYCTNYG---TKDYSNSVQWRVPLGLNFAFAIFMI 241

  Fly   228 AFLLSI-ESPVDLLEQGNEQGAVQALSRLQRPRAVTAETYDQVRDHRTY---VEHHRSMG---WR 285
            |.:|.: |||..|:|:|..:.|.::|::..:   ||.|....|.:..|.   ||..|..|   |.
Yeast   242 AGMLMVPESPRFLVEKGRYEDAKRSLAKSNK---VTIEDPSIVAEMDTIMANVETERLAGNASWG 303

  Fly   286 H-------ALPALVRLSVLRALYALSLSVMVAFTLAWTSTEVYG--DSSGPYVLFGFLRLMGSFT 341
            .       .||.::...::::|..|: .....|....|.....|  ||....::.|.:....:|.
Yeast   304 ELFSNKGAILPRVIMGIMIQSLQQLT-GNNYFFYYGTTIFNAVGMKDSFQTSIVLGIVNFASTFV 367

  Fly   342 TSFALDSLGRKIPLLLGLVISGCLA-C-------GLASRFAGSHPLTFS---GNRMALWLLLIYQ 395
            ..:.:|..||:..||.|   |..:| |       |:.|.:........|   ||.|.::..|...
Yeast   368 ALYTVDKFGRRKCLLGG---SASMAICFVIFSTVGVTSLYPNGKDQPSSKAAGNVMIVFTCLFIF 429

  Fly   396 LFAGIAFAPSSSYL-SEAFPRRIKRPCIAIT--------YILEIIVQLLLRQMDFAAIGSDSSYV 451
            .|| |::||.:..: :|::|.|:|...:||.        :::......:.     :|||....||
Yeast   430 FFA-ISWAPIAYVIVAESYPLRVKNRAMAIAVGANWIWGFLIGFFTPFIT-----SAIGFSYGYV 488

  Fly   452 ALYFFILGGLLLAGFLFSVWYMPETKDTTLLQAQFKFQEFVIP 494
            .:      |.|:..|.:..:::.|||..||.:....:.|.|.|
Yeast   489 FM------GCLVFSFFYVFFFVCETKGLTLEEVNEMYVEGVKP 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32053	NP_729587.1	MFS	73..428	CDD:119392	97/422 (23%)
HXT2	NP_013724.1	Sugar_tr	59..519	CDD:395036	113/493 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342688
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740