DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32053 and SLC2A4

DIOPT Version :9

Sequence 1:	NP_729587.1	Gene:	CG32053 / 39178	FlyBaseID:	FBgn0052053	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001033.1	Gene:	SLC2A4 / 6517	HGNCID:	11009	Length:	509	Species:	Homo sapiens

Alignment Length:	522	Identity:	123/522 - (23%)
Similarity:	189/522 - (36%)	Gaps:	141/522 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PQANAVGAAAL-IF--LTGGVHIAWSIG--------FDSSLSE------------------LEVT 89
            ||....|...| :|  :.|.:...::||        .:.|.:|                  |...
Human    16 PQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTL 80

  Fly    90 NHVQICWF-IGAIIGALLGGFFSRWFPYKTLMEFCSLITITGGIVMAVNR--MDLDALLAGRYMN 151
            ..:.:..| :|.:|.:.|.|..|:|...|..|...:::.:.||.:|.:..  ...:.|:.||::.
Human    81 WALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLI 145

  Fly   152 GLANGLAIAPTLAMAGELSVFYKRGTTTSAAEQWPTTIGIFVQIVCSHSWDVQSDFTEEQFQGVL 216
            |..:||.........||::..:.|| ......|....|||.:..|..    ::|.........:|
Human   146 GAYSGLTSGLVPMYVGEIAPTHLRG-ALGTLNQLAIVIGILIAQVLG----LESLLGTASLWPLL 205

  Fly   217 SGVLGSIALLLAFLLSI--ESPVDL-LEQGNEQGAVQALSRLQRPRAVTAETYDQVRDHRTYVEH 278
            .|:....|||...||..  |||..| :.|..|..|.::|.||.....|:. ...:::|.:..:|.
Human   206 LGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSG-VLAELKDEKRKLER 269

  Fly   279 HRS------MGWR-HALPALV--------RLSVLRALYALSLSVMVAFTLAWTSTEVYGDSSGPY 328
            .|.      :|.| |..|.::        :||.:.|::..|.|:.          |..|.....|
Human   270 ERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIF----------ETAGVGQPAY 324

  Fly   329 VLFGFLRLMGSFTTSFALDSL------GRKIPLLLGLVISGCLACGLASRFAGSHPLTFSGNRMA 387
            ...|    .|...|.|.|.|:      ||:...||||  :|...|.:.               |.
Human   325 ATIG----AGVVNTVFTLVSVLLVERAGRRTLHLLGL--AGMCGCAIL---------------MT 368

  Fly   388 LWLLLIYQLFAGIAFAPSSSYLSEAFPRRIKRPCIAI---TYILEI--------IVQLLLRQ--- 438
            :.|||:.::       |:.||:|          .:||   ....||        ||..|..|
Human   369 VALLLLERV-------PAMSYVS----------IVAIFGFVAFFEIGPGPIPWFIVAELFSQGPR 416

  Fly   439 ---MDFAA---------IGSDSSYVA----LYFFILGGLLLAG-FLFSVWYMPETKDTTLLQAQF 486
               |..|.         ||....|||    .|.|:|..:||.| |:|:...:|||:..|..|...
Human   417 PAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISA 481

  Fly   487 KF 488
            .|
Human   482 AF 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32053	NP_729587.1	MFS	73..428	CDD:119392	90/410 (22%)
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269\|PubMed:16647043	7..13
		Sugar_tr	27..483	CDD:306568	118/509 (23%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		2/5 (40%)
		Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:8300557	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144207
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840