DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32053 and Slc2a6

DIOPT Version :9

Sequence 1:	NP_729587.1	Gene:	CG32053 / 39178	FlyBaseID:	FBgn0052053	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_766247.2	Gene:	Slc2a6 / 227659	MGIID:	2443286	Length:	497	Species:	Mus musculus

Alignment Length:	496	Identity:	116/496 - (23%)
Similarity:	196/496 - (39%)	Gaps:	96/496 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LRNQPQANAVGAAALIFLTGGVHIAWSIGFDSS-LSELEVT-------NHVQICWF-----IGAI 101
            |:|:....|..||.|    |.....:::.:.|. :.||:::       :.:|..||     :||.
Mouse    32 LKNRRVFLATFAAVL----GNFSFGYALVYTSPVIPELKLSSDPALHLDKIQASWFGSVFTLGAA 92

  Fly   102 IGALLGGFFSRWFPYKTLMEFCSLITITGGIVMAVNRMDLDALLAGRYMNGLANGLAIAPTLAMA 166
            .|.|.....:.....|..:.|.::.:..|..:||..| .|..||.||.:.|.|.||..|......
Mouse    93 AGGLSAMLLNDLLGRKLSIMFSAVPSAIGYAIMAGAR-GLWMLLLGRMLTGFAGGLTAACIPVYV 156

  Fly   167 GELSVFYKRGTTTSAAEQWPTTIGIFVQIVCSHSWDVQSDFTEEQFQGVLS----GVL------- 220
            .|::....||    |....|..:.:|                     |.||    |:|
Mouse   157 SEIAPPDVRG----ALGATPQLMAVF---------------------GSLSLYALGLLLPWRWLA 196

  Fly   221 ----GSIALLLAFLLSI--ESPVDLLEQGNEQGAVQALSRLQRPRAVTAETYDQVRDHRTYVEHH 279
                |.: |::..|||.  .||..||.:..::.|:|||:.|:....|..| ::|::|:   |...
Mouse   197 VAGEGPV-LIMILLLSFMPNSPRFLLSKSRDEEALQALTWLRADSEVHWE-FEQIQDN---VRRQ 256

  Fly   280 RS-MGWRHA------LPALVRLSVLRALYALS--LSVMVAFTLAWTSTEVYGDSSGPYVLFGFLR 335
            .| :.|..|      .|.|:.: ::|.|..|:  ..::|.....:.:|.|...|.....:.|.:|
Mouse   257 SSRVSWAEAREPRVYRPVLIAV-LMRFLQQLTGITPILVYLQTIFDNTSVVLPSQQDAAIVGAVR 320

  Fly   336 LMGSFTTSFALDSLGRKIPLLL--GLVISGCLACGLASRFAGSHPLTFSG------------NRM 386
            |:.....:..:|..|||:.|.:  .::.:..|..||..:|. ..|||.:.            |.:
Mouse   321 LLSVLIAAVTMDLAGRKVLLYVSASVMFAANLTLGLYVQFV-PRPLTPNSTVEIVTLGDTAFNYL 384

  Fly   387 ALWLLLIYQLFA---GIAFAPSSSYL-SEAFPRRIKRPCIAITYILEIIVQLLLRQMDFAAIGSD 447
            .|..||...||.   .:.:.|.:..| ||..|.|.:.....:..::..:...:|......|:.:.
Mouse   385 TLIPLLATMLFIMGYAMGWGPITWLLMSEVLPLRARGVASGLCVLVSWLTAFVLTNYFLLAVNAF 449

  Fly   448 SSYVALYFFILGGLLLAGFLFSVWYMPETKDTTLLQAQFKF 488
            ...|..:||  ..:.|...||:...:|||:..:|.|.:..|
Mouse   450 GLQVPFFFF--SAICLLSLLFTGCCVPETRGRSLEQIEAFF 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32053	NP_729587.1	MFS	73..428	CDD:119392	95/411 (23%)
Slc2a6	NP_766247.2	Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS	38..483	CDD:391944	112/483 (23%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	284..290		1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834400
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740