Protein Alignment CG14160 and SLC2A3

DIOPT Version :10

• Sequence 1: NP_648380.2
• Gene: CG14160 / 39177
• FlyBaseID: FBgn0036066
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Alignment Length: 472
• Identity: 104/472 - (22%)
• Similarity: 194/472 - (41%)
• Gaps: 93/472 - (19%)

  Fly    31 SASIVFVGCGMRLAWSIFDTPAGKFLNNHNTHNLMMSWFIGAAVGALLAALFVQRVTKNVAYTSS 95
            |.:|..|| ||..::|:     |.|:|.....|.|:...:.|..|.....|.  :|.|:|.
Human    66 SVAIFSVG-GMIGSFSV-----GLFVNRFGRRNSMLIVNLLAVTGGCFMGLC--KVAKSVE---- 118

  Fly    96 GFLMIIAGILNVVLPQHFLAACYSSVSVGAAYGLTQIQALVTGSEVAHKSIRGMLLSCEKIFLWL 160
               |:|.|.|.:.|   |...|            |....:..| |::..::||...:..::.:.:
Human   119 ---MLILGRLVIGL---FCGLC------------TGFVPMYIG-EISPTALRGAFGTLNQLGIVV 164

  Fly   161 GVCM-QVFYTRVWHNLRPLDTQGYEMHI--DQLHGMVLAGLGLGAVI--LALAHRLESP-LLLLH 219
            |:.: |:|              |.|..:  ::|..::|....|.|::  .||....||| .||::
Human   165 GILVAQIF--------------GLEFILGSEELWPLLLGFTILPAILQSAALPFCPESPRFLLIN 215

  Fly   220 QERDMAVGETLKALHG-QSTTELVRLREDCRQLHSARDWERFVEEPEESVADWRVWARRILPFFK 283
            ::.:....:.|:.|.| |..::.::..:|    .||    |..:|.:.:|.:    ..|:..:.:
Human   216 RKEEENAKQILQRLWGTQDVSQDIQEMKD----ESA----RMSQEKQVTVLE----LFRVSSYRQ 268

  Fly   284 VLLLRCFATLAVSLS-YNRAFVVVSWHGLECDMNC---MYWLAFAGLIG---SVLGAFVVDWQGR 341
            .:::.....|:..|| .|..|...:  |:..|...   :|....||::.   :|:..|:|:..||
Human   269 PIIISIVLQLSQQLSGINAVFYYST--GIFKDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGR 331

  Fly   342 RKVCSLSL----FLAGVVIVMVGGVFDHLESVKRSFYDINLLVIALLMLLFEVIVAGGVAVPALV 402
            |.:..:.|    |.:.::.|.:        .:|.::..::.:.|..:::.......|...:|..:
Human   332 RTLHMIGLGGMAFCSTLMTVSL--------LLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFI 388

  Fly   403 YTAEAFSIAHK--ARCLAGILIVEQLLQLGLLLATFEHYITVSVFFFTIGVFSFIVGLTVFMF-- 463
             .||.||...:  |..:||.........:|||..:..||:...||....|   |::....|.|
Human   389 -VAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTG---FLITFLAFTFFK 449

  Fly   464 MPETRQLTLYECLLKFK 480
            :||||..|..:....|:
Human   450 VPETRGRTFEDITRAFE 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14160	NP_648380.2	None
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	102/460 (22%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)