DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6674 and TSSC4

DIOPT Version :9

Sequence 1:	NP_648377.1	Gene:	CG6674 / 39174	FlyBaseID:	FBgn0036063	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	NP_001284587.1	Gene:	TSSC4 / 10078	HGNCID:	12386	Length:	329	Species:	Homo sapiens

Alignment Length:	229	Identity:	58/229 - (25%)
Similarity:	88/229 - (38%)	Gaps:	62/229 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FSAKRDALFACLDDASKELRGTALDQSKAKAFSINALDRGNKSGNESGQVMNYRQ-----GRSIV 63
            ||.:...:|.||:.|::....:....|.:        |.|           .:::     |||.|
Human    89 FSQRSRDIFDCLEGAARRAPSSVAHTSMS--------DNG-----------GFKRPLAPSGRSPV 134

  Fly    64 TGLDAEDGRLRRMRGKESIFKKPELPIGRCLKPRKTPDYQVNPHKWKKYSLSDV-DISEQSNSAA 127
            .||    ||..|...      .|.:|        ..|||..:|.:|.||||.|| ::|||||.|.
Human   135 EGL----GRAHRSPA------SPRVP--------PVPDYVAHPERWTKYSLEDVTEVSEQSNQAT 181

  Fly   128 ALSFLRQMDAQREAEGVDNESPPTDGKIEFKRTSKLSRKLKSLKQQEVDDVELDKPQLRGSKLVM 192
            ||:||          |..:.:.|||....|.:......:.:.:..:.|..||....:.|
Human   182 ALAFL----------GSQSLAAPTDCVSSFNQDPSSCGEGRVIFTKPVRGVEARHERKR------ 230

  Fly   193 PEYVIGQKPHKPKKCKTKSEQSRAAGKLQLSHLA 226
               |:|:.....:.........|..|.::|:|||
Human   231 ---VLGKVGEPGRGGLGNPATDRGEGPVELAHLA 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6674	NP_648377.1	TSSC4	9..149	CDD:291916	40/145 (28%)
TSSC4	NP_001284587.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..88
		TSSC4	94..210	CDD:291916	44/162 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..156		16/88 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..329		11/50 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160485
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2B0B3
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006071
OrthoInspector	1	1.000	-	-		oto89548
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13445
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8177
SonicParanoid	1	1.000	-	-		X5789
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.960