Protein Alignment Dronc and CFLAR

DIOPT Version :10

• Sequence 1: NP_524017.1
• Gene: Dronc / 39173
• FlyBaseID: FBgn0026404
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_003870.4
• Gene: CFLAR / 8837
• HGNCID: 1876
• Length: 480
• Species: Homo sapiens
• Alignment Length: 280
• Identity: 62/280 - (22%)
• Similarity: 114/280 - (40%)
• Gaps: 62/280 - (22%)

  Fly    53 QDLNGKPFNMDEK---DVRVEQHRRLLLKITQRGPTAYNLLINALRNINCLDAAVLLESVDESDS 114
            :|..|:.....||   |:.||     |.|:....|...:||...|:||:.:|....::...:
Human   117 KDYMGRGKISKEKSFLDLVVE-----LEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQ--- 173

  Fly   115 RPPFISLNERRTSRKSADIVDTPSPEASEGPCVS-KLRN---------EPLGALTPYVGVVDGPE 169
                 |:....||.:  :::.....::.:.|..: :|.|         |.|||        ....
Human   174 -----SVQGAGTSYR--NVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGA--------QQEP 223

  Fly   170 VKKSKKIHGGDSAILGT-----YKMQSRFNRGVLLMVNIMDYPDQNRRRIGAEKDSKSLIHLFQE 229
            ||||  |...::.:..:     |||:|: ..|:.|:::.          ||.|  ::.|...|..
Human   224 VKKS--IQESEAFLPQSIPEERYKMKSK-PLGICLIIDC----------IGNE--TELLRDTFTS 273

  Fly   230 LNFTIFPYGNVNQDQFFKLLTMVTSSSYVQNTECFVMVLMTHG--NSVEGKEKVEFCDGSVVDMQ 292
            |.:.:..:.:::.....::|.........::.:.||.||::.|  .||.|.::..    |.:.:.
Human   274 LGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTH----SGLPLH 334

  Fly   293 KIKDHFQTAKCPYLVNKPKV 312
            .|:..|....||||..|||:
Human   335 HIRRMFMGDSCPYLAGKPKM 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	16/55 (29%)
		CASc	186..443	CDD:237997	31/134 (23%)
CFLAR	NP_003870.4	Not proteolytically processed and involved in apoptosis inhibition	1..435		62/280 (22%)
		Interaction with CASP8 propeptide. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	1..305		44/225 (20%)
		Interaction with FADD. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	1..227		28/132 (21%)
		Interaction with CASP8. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	1..195		19/92 (21%)
		DED_c-FLIP_r1	1..80	CDD:260044
		DED_c-FLIP_r2	91..171	CDD:260046	16/58 (28%)
		Interaction with TRAF1 and TRAF2. /evidence=ECO:0000269|PubMed:9208847	192..480		43/190 (23%)
		Interaction with CASP3. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	192..435		43/190 (23%)
		Interaction with CASP8 subunits p18 and p10. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	217..480		39/165 (24%)
		CASc	244..479	CDD:214521	31/128 (24%)
		Caspase	263..358		23/98 (23%)
		Interaction with CASP8. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	370..480