DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dronc and CFLAR

DIOPT Version :9

Sequence 1:NP_524017.1 Gene:Dronc / 39173 FlyBaseID:FBgn0026404 Length:450 Species:Drosophila melanogaster
Sequence 2:NP_001120655.1 Gene:CFLAR / 8837 HGNCID:1876 Length:480 Species:Homo sapiens


Alignment Length:280 Identity:62/280 - (22%)
Similarity:114/280 - (40%) Gaps:62/280 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 QDLNGKPFNMDEK---DVRVEQHRRLLLKITQRGPTAYNLLINALRNINCLDAAVLLESVDESDS 114
            :|..|:.....||   |:.||     |.|:....|...:||...|:||:.:|....::...:   
Human   117 KDYMGRGKISKEKSFLDLVVE-----LEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQ--- 173

  Fly   115 RPPFISLNERRTSRKSADIVDTPSPEASEGPCVS-KLRN---------EPLGALTPYVGVVDGPE 169
                 |:....||.:  :::.....::.:.|..: :|.|         |.|||        ....
Human   174 -----SVQGAGTSYR--NVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGA--------QQEP 223

  Fly   170 VKKSKKIHGGDSAILGT-----YKMQSRFNRGVLLMVNIMDYPDQNRRRIGAEKDSKSLIHLFQE 229
            ||||  |...::.:..:     |||:|: ..|:.|:::.          ||.|  ::.|...|..
Human   224 VKKS--IQESEAFLPQSIPEERYKMKSK-PLGICLIIDC----------IGNE--TELLRDTFTS 273

  Fly   230 LNFTIFPYGNVNQDQFFKLLTMVTSSSYVQNTECFVMVLMTHG--NSVEGKEKVEFCDGSVVDMQ 292
            |.:.:..:.:::.....::|.........::.:.||.||::.|  .||.|.::..    |.:.:.
Human   274 LGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTH----SGLPLH 334

  Fly   293 KIKDHFQTAKCPYLVNKPKV 312
            .|:..|....||||..|||:
Human   335 HIRRMFMGDSCPYLAGKPKM 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DroncNP_524017.1 CARD 18..106 CDD:260018 16/55 (29%)
CASc 186..443 CDD:237997 31/134 (23%)
CFLARNP_001120655.1 Not proteolytically processed and involved in apoptosis inhibition 1..435 62/280 (22%)
Interaction with CASP8 propeptide. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610 1..305 44/225 (20%)
Interaction with FADD. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610 1..227 28/132 (21%)
Interaction with CASP8. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610 1..195 19/92 (21%)
DED_c-FLIP_r1 1..80 CDD:260044
DED_c-FLIP_r2 91..171 CDD:260046 16/58 (28%)
Interaction with TRAF1 and TRAF2. /evidence=ECO:0000269|PubMed:9208847 192..480 43/190 (23%)
Interaction with CASP3. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610 192..435 43/190 (23%)
Interaction with CASP8 subunits p18 and p10. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610 217..480 39/165 (24%)
CASc 244..479 CDD:214521 31/128 (24%)
Caspase 263..358 23/98 (23%)
Interaction with CASP8. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610 370..480
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152736
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3573
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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