Protein Alignment Dronc and CASP10

DIOPT Version :9

• Sequence 1: NP_524017.1
• Gene: Dronc / 39173
• FlyBaseID: FBgn0026404
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_116759.2
• Gene: CASP10 / 843
• HGNCID: 1500
• Length: 522
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 121/527 - (22%)
• Similarity: 202/527 - (38%)
• Gaps: 141/527 - (26%)

  Fly    18 IRKNLNILVEWTNYERLAMECVQQGILTVQMLRNT------------QDLNGK--PFNMDEKDVR 68
            |..||.:    .:.|.|...|:  |::..:.|..:            :||..:  ||.:.|....
Human    27 IDSNLGV----QDVENLKFLCI--GLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAELLYI 85

  Fly    69 VEQHRRL------------LLKITQRGPTAYNLLINALRNI---NCLDAAVLLESVDESDSRP-- 116
            :.|.:.|            ||...||.....|||......|   |..|...||:     ||.|
Human    86 IRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLK-----DSLPKT 145

  Fly   117 -----PFISLNERRTSRKSADIVDTPSPEASEGPC---VSKL--------RNEPLGALTP----- 160
                 .|::..|::..      :|..:....|..|   |.||        |.:.:..:||
Human   146 EMTSLSFLAFLEKQGK------IDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKE 204

  Fly   161 ---YVG---VVDGPEVKK------------------------------SKKIHGGDSAILGT--- 186
               |.|   :|...:||.                              |:.:.|..:..|.:
Human   205 AESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETS 269

  Fly   187 ------YKMQSRFNRGVLLMVNIMDYPDQNRRRIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQF 245
                  |:| :|.:||:.::||...:.....|: |..||::.|.|:||.|.||:..:.||.:.:.
Human   270 TKRAAVYRM-NRNHRGLCVIVNNHSFTSLKDRQ-GTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332

  Fly   246 FKLLTMVTSSSYVQNTECFVMVLMTHGNSVEGKEKVEFCDGSVVDMQKIKDHFQTAKCPYLVNKP 310
            ..:|.....:....:.:|||..::|||..    ..|...|.:::.:::|..||...:||.|..||
Human   333 EMVLQKQKCNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIREIMSHFTALQCPRLAEKP 393

  Fly   311 KVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPSPSTNVPSLADTLVCYANTP 375
            |:.....|:|:|            ::|..:.:.:.....|..  .|...::|:.||.|:..|..|
Human   394 KLFFIQACQGEE------------IQPSVSIEADALNPEQAP--TSLQDSIPAEADFLLGLATVP 444

  Fly   376 GYVTHRDLDTGSWYIQKFC----QVMADHAHDTDLEDILKKTSEAVGNKRTKKGSMQTGAYDNLG 436
            |||:.|.::.||||||..|    :::..|   .|:..||...::.|..:..|:|:.:........
Human   445 GYVSFRHVEEGSWYIQSLCNHLKKLVPRH---EDILSILTAVNDDVSRRVDKQGTKKQMPQPAFT 506

  Fly   437 FNKKLYF 443
            ..|||.|
Human   507 LRKKLVF 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	25/116 (22%)
		CASc	186..443	CDD:237997	71/269 (26%)
CASP10	NP_116759.2	DD	18..99	CDD:326335	15/77 (19%)
		DED_Caspase_10_r2	112..190	CDD:260074	19/88 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..269		3/37 (8%)
		CASc	276..514	CDD:214521	72/261 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810