Protein Alignment Dronc and CASP9

DIOPT Version :9

• Sequence 1: NP_524017.1
• Gene: Dronc / 39173
• FlyBaseID: FBgn0026404
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: XP_011540575.1
• Gene: CASP9 / 842
• HGNCID: 1511
• Length: 421
• Species: Homo sapiens
• Alignment Length: 469
• Identity: 107/469 - (22%)
• Similarity: 189/469 - (40%)
• Gaps: 99/469 - (21%)

  Fly    10 MPKRHREHIRKNLNILVEWTNYERLAMECVQQGILTVQMLRNTQDLNGKPFNMDEKDVRVEQHRR 74
            |.:..|..:|:....|||....::|....:.:.:....|:.:.|...        ...|.:|.|:
Human     1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAG--------SGSRRDQARQ 57

  Fly    75 LLLKITQRGPTAYNLLINALRNINCLDAAVLLESVDESDSRPPFISLNERRTSRKSADIVDTPSP 139
            |::.:..||..|..|.|:.|.:..             .|....|:     ||:|::|
Human    58 LIIDLETRGSQALPLFISCLEDTG-------------QDMLASFL-----RTNRQAA-------- 96

  Fly   140 EASEGPCVSKLRNEPLGALTPYVGVVDGPEVKKSKKIHG-------------GDSAILGTYK--- 188
                     ||....|..|||   ||..||::|.:.:..             ||...|.:.:
Human    97 ---------KLSKPTLENLTP---VVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNA 149

  Fly   189 ----MQSRFNRGVLLMVNIMDYPDQN--RRRIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQFFK 247
                :.|....|..|::|.:::..::  |.|.|:..|.:.|...|..|:|.:...|::...:...
Human   150 DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVL 214

  Fly   248 LLTMVTSSSYVQNTECFVMVLMTHG---NSVEGKEKVEFCDGSVVDMQKIKDHFQTAKCPYLVNK 309
            .|..:....: ...:|.|:|:::||   :.::....|...||..|.::||.:.|....||.|..|
Human   215 ALLELAQQDH-GALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGK 278

  Fly   310 PKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPSP-------------STNV 361
            ||:.....|.|::.|.|        .|...|:.|::.|.:..|...:|             .:::
Human   279 PKLFFIQACGGEQKDHG--------FEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSL 335

  Fly   362 PSLADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSEAV---GNKRTK 423
            |:.:|..|.|:..||:|:.||..:||||::....:....||..||:.:|.:.|.|.   |..|..
Human   336 PTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVSAAFLCKGEGRLL 400

  Fly   424 KGSMQTGAYDNLGF 437
            :||:.:..:   ||
Human   401 RGSVSSWGW---GF 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	17/87 (20%)
		CASc	186..443	CDD:237997	68/280 (24%)
CASP9	XP_011540575.1	CARD_CASP9	17..90	CDD:176740	17/98 (17%)
		CASc	152..397	CDD:237997	63/253 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152748
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1092723at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750