Protein Alignment Dronc and CASP8

DIOPT Version :10

• Sequence 1: NP_524017.1
• Gene: Dronc / 39173
• FlyBaseID: FBgn0026404
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_001073594.1
• Gene: CASP8 / 841
• HGNCID: 1509
• Length: 538
• Species: Homo sapiens
• Alignment Length: 458
• Identity: 110/458 - (24%)
• Similarity: 187/458 - (40%)
• Gaps: 89/458 - (19%)

  Fly    22 LNILVEWTNYERLAMECVQQ--GILTVQMLR----------NTQDLNGKPFNMDEK--------- 65
            |::|:.:.|..:..||...|  |...:...|          :..:|....|.:.|:
Human   131 LDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDD 195

  Fly    66 ----DVRVEQHRRLLLKITQRGPTAYNLLINALRNINCLDAAVLLESVDESDSRPPFISLNERRT 126
                |:.:|..:|::|     |....::|......||    ..||:.:::          .|..:
Human   196 MNLLDIFIEMEKRVIL-----GEGKLDILKRVCAQIN----KSLLKIIND----------YEEFS 241

  Fly   127 SRKSADIVDTPSPEASEGPCVSKLRNEPLGALTPYVGVVDGPEVKKSKKIHGGDSAILGTYKMQS 191
            ..:|:.:..:|. |.|.|       .|..|.:|    :.|.|..:.|:     ...:...|:|:|
Human   242 KERSSSLEGSPD-EFSNG-------EELCGVMT----ISDSPREQDSE-----SQTLDKVYQMKS 289

  Fly   192 RFNRGVLLMVNIMDYPDQN---------RRRIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQFFK 247
            : .||..|::|..::....         |.|.|...|:.:|...|:||:|.|.|:.:...:|.::
Human   290 K-PRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYE 353

  Fly   248 LLTMVTSSSYVQNTECFVMVLMTHGNSVEGKEKVEFCDGSVVDMQKIKDHFQTAKCPYLVNKPKV 312
            :|.:.....: .|.:||:..:::||:    |..:...||....:.::...|...|||.|..||||
Human   354 ILKIYQLMDH-SNMDCFICCILSHGD----KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKV 413

  Fly   313 LMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPSPSTN-VPSLADTLVCYANTPG 376
            .....|:||.|..|         .||.|..||: |..:.: :.||.|. :|..||.|:..|....
Human   414 FFIQACQGDNYQKG---------IPVETDSEEQ-PYLEMD-LSSPQTRYIPDEADFLLGMATVNN 467

  Fly   377 YVTHRDLDTGSWYIQKFCQVMADHA-HDTDLEDILKKTSEAVGNKRTKKGSMQTGAYDNLGFNKK 440
            .|::|:...|:||||..||.:.:.. ...|:..||.:.:..|.||..||...:..........||
Human   468 CVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKK 532

  Fly   441 LYF 443
            |.|
Human   533 LVF 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	19/108 (18%)
		CASc	186..443	CDD:237997	76/267 (28%)
CASP8	NP_001073594.1	DED_Caspase_8_r1	62..143	CDD:260041	3/11 (27%)
		DD	157..239	CDD:472698	14/100 (14%)
		CASc	284..536	CDD:237997	77/269 (29%)