DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dronc and CASP6

DIOPT Version :9

Sequence 1:	NP_524017.1	Gene:	Dronc / 39173	FlyBaseID:	FBgn0026404	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001217.2	Gene:	CASP6 / 839	HGNCID:	1507	Length:	293	Species:	Homo sapiens

Alignment Length:	280	Identity:	75/280 - (26%)
Similarity:	131/280 - (46%)	Gaps:	47/280 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 YKMQSRFNRGVLLMVN------IMDYPDQNRRRIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQF 245
            |||..| .||:.|:.|      .:..|:  ||...|::|  :|...|.:|.|.:..:.::..::.
Human    37 YKMDHR-RRGIALIFNHERFFWHLTLPE--RRGTCADRD--NLTRRFSDLGFEVKCFNDLKAEEL 96

  Fly   246 FKLLTMVTSSSYVQNTECFVMVLMTHGNSVEGKEKVEFCDGSVVDMQKIKDHFQTAKCPYLVNKP 310
            ...:..|::.|:. :.:|||.|.::||   ||.....:  .:.:::|.:...|:..||..||.||
Human    97 LLKIHEVSTVSHA-DADCFVCVFLSHG---EGNHIYAY--DAKIEIQTLTGLFKGDKCHSLVGKP 155

  Fly   311 KVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPSPSTNV--------PSLADT 367
            |:.:...|||:::|:           ||.....   .|.|||.:.:..|.|        |:.||.
Human   156 KIFIIQACRGNQHDV-----------PVIPLDV---VDNQTEKLDTNITEVDAASVYTLPAGADF 206

  Fly   368 LVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSEAVGNKR-------TKKG 425
            |:||:...||.:||:...||||||..|:::..:....:..::|...:..|..:|       :..|
Human   207 LMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIG 271

  Fly   426 SMQTGAYDNLGFNKKLYFNP 445
            ..|...:.:: ..|||:|.|
Human   272 KKQVPCFASM-LTKKLHFFP 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018
Dronc	NP_524017.1	CASc	186..443	CDD:237997	73/276 (26%)
CASP6	NP_001217.2	CASc	37..290	CDD:214521	74/278 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152728
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840