Protein Alignment Dronc and CASP5

DIOPT Version :10

• Sequence 1: NP_524017.1
• Gene: Dronc / 39173
• FlyBaseID: FBgn0026404
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_001129584.1
• Gene: CASP5 / 838
• HGNCID: 1506
• Length: 447
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 95/473 - (20%)
• Similarity: 175/473 - (36%)
• Gaps: 108/473 - (22%)

  Fly    30 NYERLAMECVQQGI---LTVQMLRNTQDLNGKPF------NMDEK--DVRVEQHRRLLLKITQ-R 82
            |:|.:....:|.|:   :...||:|  ::.|:..      |.|:|  .|:.:.|::..:|:.: .
Human    26 NFEAMFKGILQSGLDNFVINHMLKN--NVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYL 88

  Fly    83 GPTAYNLLINALRNINCL-----------------DAAVLLES-----VDESDSRPPFISLNERR 125
            |....:.:.|.|...:.|                 .|.:|::|     |.........::::::.
Human    89 GKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLRKNRVAHQMFTQTLLNMDQKI 153

  Fly   126 TSRKSADIVDTPSPEASEGPCVSKL--RNEPLGALTPYVGVVDGPEVKKSKKIHGGDSAILGTYK 188
            ||.|....::...||::|...:.||  |.|.|               :..||.|.      ..|.
Human   154 TSVKPLLQIEAGPPESAESTNILKLCPREEFL---------------RLCKKNHD------EIYP 197

  Fly   189 MQSRFNRGVLLMVNIMDYPDQNRRRIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQFFKLLTMVT 253
            ::.|.:|..|.::......|....|.||..|...:..|.|.|.:|:....|:.......:|....
Human   198 IKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFA 262

  Fly   254 SSSYVQNTECFVMVLMTHGNSVEG-------KEKVEFCDGSVVDMQKIKDHFQTAKCPYLVNKPK 311
            :....::::...:|||:|| .:||       |:|.:     |:....|...|....|..|.:|||
Human   263 ARPEHKSSDSTFLVLMSHG-ILEGICGTAHKKKKPD-----VLLYDTIFQIFNNRNCLSLKDKPK 321

  Fly   312 VLMFPFCRGDEYD------------LGHPKNQGNL-MEPVYTAQEEKWPDTQTEGIPSPSTNVPS 363
            |::...|||:::.            |...::..|| .:.|....|||
Human   322 VIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEK------------------ 368

  Fly   364 LADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSEAVGNKRTKKGSMQ 428
              |.:...::||..|:.||...||.:|.:.......::....|.:|.:|..::.   ...:...|
Human   369 --DFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF---EVPQAKAQ 428

  Fly   429 TGAYDNLGFNKKLYFNPG 446
            ....:.....:..|..||
Human   429 MPTIERATLTRDFYLFPG 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	19/104 (18%)
		CASc	186..443	CDD:237997	56/276 (20%)
CASP5	NP_001129584.1	DD	76..155	CDD:472698	10/78 (13%)
		CASc	196..445	CDD:214521	57/277 (21%)