Protein Alignment Dronc and CASP4

DIOPT Version :9

• Sequence 1: NP_524017.1
• Gene: Dronc / 39173
• FlyBaseID: FBgn0026404
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_001216.1
• Gene: CASP4 / 837
• HGNCID: 1505
• Length: 377
• Species: Homo sapiens
• Alignment Length: 447
• Identity: 94/447 - (21%)
• Similarity: 172/447 - (38%)
• Gaps: 93/447 - (20%)

  Fly    17 HIRKNLNILVEWTNYERLAMECVQQGILTVQMLRNTQDLNGKPFNMDEK----DVRVEQHRRLLL 77
            |.:|.|.:|           |.:.:..|| .:|.|..:.|...:..:||    |.:.|...|
Human     6 HRKKPLKVL-----------ESLGKDFLT-GVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVR--- 55

  Fly    78 KITQRGPTAYNLLINALRNINCLDAAVLLESVDESDSRPPFISLNERRTSRKSADIVDTPSPEAS 142
                       ::.::::....:...:||::         |.::::...::|:...::...||:.
Human    56 -----------VMADSMQEKQRMAGQMLLQT---------FFNIDQISPNKKAHPNMEAGPPESG 100

  Fly   143 EGPCVSKL-RNEPLGALTPYVGVVDGPEVKKSKKIHGGDSAILGTYKMQSRFNRGVLLMVNIMDY 206
            |.....|| .:|....|..          :::::|          |.::.|.||..|.::.....
Human   101 ESTDALKLCPHEEFLRLCK----------ERAEEI----------YPIKERNNRTRLALIICNTE 145

  Fly   207 PDQNRRRIGAEKDSKSLIHLFQELNFTIFPYGNVN-QDQFFKLLTMVTSSSYVQNTECFVMVLMT 270
            .|....|.||:.|...:..|.:.|::::....|:. :|....|....|...:..:...| :|||:
Human   146 FDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTF-LVLMS 209

  Fly   271 HGNSVEGKEKVEFCDGSVVDMQK--------IKDHFQTAKCPYLVNKPKVLMFPFCRGDEYDLGH 327
            || .:||     .| |:|.|.:|        |...|....|..|.:||||::...|||
Human   210 HG-ILEG-----IC-GTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG------- 260

  Fly   328 PKNQGNLMEPVYTAQEEKWPDTQTEGIPSPS---TNVPSLADTLVCYANTPGYVTHRDLDTGSWY 389
             .|:|.|......|..|......:|.:...:   |:|..  |.:...::||..|:.||...||.:
Human   261 -ANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEK--DFIAFCSSTPHNVSWRDSTMGSIF 322

  Fly   390 IQKFCQVMADHAHDTDLEDILKKTSEAVGNKRTKKGSMQTGAYDNLGFNKKLYFNPG 446
            |.:.......::....||::.:|..::....|.|   .|....:.|...:..|..||
Human   323 ITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK---AQMPTIERLSMTRYFYLFPG 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	14/91 (15%)
		CASc	186..443	CDD:237997	64/268 (24%)
CASP4	NP_001216.1	Required for LPS-binding. /evidence=ECO:0000250|UniProtKB:P70343	1..59		15/78 (19%)
		CARD_CASP1-like	5..81	CDD:260036	18/109 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..104		4/19 (21%)
		CASc	126..375	CDD:214521	65/269 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152726
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.700