Protein Alignment Dronc and CASP3

DIOPT Version :10

• Sequence 1: NP_524017.1
• Gene: Dronc / 39173
• FlyBaseID: FBgn0026404
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_004337.2
• Gene: CASP3 / 836
• HGNCID: 1504
• Length: 277
• Species: Homo sapiens
• Alignment Length: 308
• Identity: 72/308 - (23%)
• Similarity: 130/308 - (42%)
• Gaps: 69/308 - (22%)

  Fly   165 VDGPEVK--KSKKIHGGDSAILG-----TYKMQSRFNRGVLLMVNIMDYPDQN--RRRIGAEKDS 220
            ||...:|  :.|.|||.:|...|     :|||... ..|:.:::|..::....  ..|.|.:.|:
Human     8 VDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYP-EMGLCIIINNKNFHKSTGMTSRSGTDVDA 71

  Fly   221 KSLIHLFQELNFTIFPYGNVNQDQFFKLLTMVTSSSYVQNTECFVMVLMTHGNSVEGKEKVEFCD 285
            .:|...|:.|.:.:....::.:::..:|:..|:...:.:.:. ||.||::|     |:|.:.|..
Human    72 ANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSS-FVCVLLSH-----GEEGIIFGT 130

  Fly   286 GSVVDMQKIKDHFQTAKCPYLVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQ 350
            ...||::||.:.|:..:|..|..|||:.:...|||.|.|.|                      .:
Human   131 NGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCG----------------------IE 173

  Fly   351 TE-GIPSPST--NVPSLADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKK 412
            |: |:.....  .:|..||.|..|:..|||.:.|:...|||:||..|.::..:|...:...||.:
Human   174 TDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTR 238

  Fly   413 TSEAVGNKRTKKGSMQTGAYDNLGFN-----------------KKLYF 443
            .:..|..:           :::..|:                 |:|||
Human   239 VNRKVATE-----------FESFSFDATFHAKKQIPCIVSMLTKELYF 275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018
		CASc	186..443	CDD:237997	61/278 (22%)
CASP3	NP_004337.2	CASc	37..277	CDD:214521	63/279 (23%)