Protein Alignment Dronc and CASP2

DIOPT Version :9

• Sequence 1: NP_524017.1
• Gene: Dronc / 39173
• FlyBaseID: FBgn0026404
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_116764.2
• Gene: CASP2 / 835
• HGNCID: 1503
• Length: 452
• Species: Homo sapiens
• Alignment Length: 444
• Identity: 110/444 - (24%)
• Similarity: 178/444 - (40%)
• Gaps: 89/444 - (20%)

  Fly     9 GMPKRHREHIRKNLNILVEWTNYERLAMECVQQGILTVQMLRNTQDLNGKPFNMDEKDVRVEQHR 73
            ||...|:|.::||..:|.:......|....:::.|:|::|....|...|.          ..|:.
Human    31 GMHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGS----------FSQNV 85

  Fly    74 RLLLKITQRGPTAYNLLINALRNI--NCLDAAVLLESVDESDSRPPFISLNERRTSRKSADI-VD 135
            .||..:.:|||.|::....|||..  ..|:..:|..........||.           |.|. :.
Human    86 ELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPL-----------SCDYDLS 139

  Fly   136 TPSPEASEGPCVSKLR-----------NEPLGALTPYVGVVDGPEVKKSK-------KIHGGDSA 182
            .|.|.....|...|||           |:            |||...:.|       :.|
Human   140 LPFPVCESCPLYKKLRLSTDTVEHSLDNK------------DGPVCLQVKPCTPEFYQTH----- 187

  Fly   183 ILGTYKMQSRFNRGVLLMVNIMDYPDQNRR--RIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQF 245
            ....|::||| .||:.|:::.:.:..:...  |.|.:.|..:|:.||:.|.:.:    :|..||
Human   188 FQLAYRLQSR-PRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDV----HVLCDQ- 246

  Fly   246 FKLLTMVTSSSYVQN---------TECFVMVLMTHGNSVEGKEKVEFCDGSVVDMQKIKDHFQTA 301
                |.......:||         |:..::.|::||  |||  .:...||.::.:|::...|..|
Human   247 ----TAQEMQEKLQNFAQLPAHRVTDSCIVALLSHG--VEG--AIYGVDGKLLQLQEVFQLFDNA 303

  Fly   302 KCPYLVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPSPSTNVPSLAD 366
            .||.|.||||:.....|||||.|.|..:..|.........:|.   |...|.:  |...:|:.:|
Human   304 NCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEES---DAGKEKL--PKMRLPTRSD 363

  Fly   367 TLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSEAVGNK 420
            .:..||...|....|:...|||||:...||.::.|.|..:.|:|.|.:..:.::
Human   364 MICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDR 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	20/89 (22%)
		CASc	186..443	CDD:237997	69/246 (28%)
CASP2	NP_116764.2	CARD_CASP2	32..118	CDD:260040	23/95 (24%)
		CASc	192..447	CDD:214521	69/245 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..354		5/31 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152730
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1092723at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.710