Protein Alignment Dronc and CASP1

DIOPT Version :9

• Sequence 1: NP_524017.1
• Gene: Dronc / 39173
• FlyBaseID: FBgn0026404
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_001244047.1
• Gene: CASP1 / 834
• HGNCID: 1499
• Length: 404
• Species: Homo sapiens
• Alignment Length: 438
• Identity: 88/438 - (20%)
• Similarity: 177/438 - (40%)
• Gaps: 69/438 - (15%)

  Fly    33 RLAMECVQQGILT--VQMLRNTQDLNGKPFNMDEKD--VRVEQHRRLLLKITQRGPTAYNLLINA 93
            :|.:..:.:|.:.  :..|..|:.||.:.....:::  ..:::.|.|:..:..:|..|..:.|..
Human    11 KLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITY 75

  Fly    94 LRNINCLDAAVLLESVDESDSRPPFISLNERRTSRKSADIVDT-PSPEASEGPCVSKLRNEPLGA 157
            :...:...|..|..|.|::...  ::::.:      |..::.: |:|:|.:.       |..:..
Human    76 ICEEDSYLAGTLGLSADQTSGN--YLNMQD------SQGVLSSFPAPQAVQD-------NPAMPT 125

  Fly   158 LTPYVGVVDGPEVKKSKKIHGGDSAILGTYKMQSRFNRGVLLMVNIMDYPDQNRRRIGAEKDSKS 222
            .:...|.|....::::::|....||.:  |.:..:.:|..|.::...:..|...||.|||.|...
Human   126 SSGSEGNVKLCSLEEAQRIWKQKSAEI--YPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITG 188

  Fly   223 LIHLFQELNFTIFPYGNVNQDQFFKLLTMVTSSSYVQNTECFV------------MVLMTHG--N 273
            :..|.|.|.:::    :|.::        :|:|......|.|.            :|.|:||  .
Human   189 MTMLLQNLGYSV----DVKKN--------LTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE 241

  Fly   274 SVEGKEKVEFCDGSVVDMQKIKDHFQTAKCPYLVNKPKVLMFPFCRGDEYDLGHPKN----QGNL 334
            .:.||:..|... .::.:..|.:...|..||.|.:||||::...||||...:...|:    .|||
Human   242 GICGKKHSEQVP-DILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNL 305

  Fly   335 MEPVYTAQEEKWPDTQTEGIPSPSTNVPSLADTLVCY-ANTPGYVTHRDLDTGSWYIQKFCQVMA 398
            ..|.            ||.....:.....:....:.: ::||..|:.|....||.:|.:..:.|.
Human   306 SLPT------------TEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQ 358

  Fly   399 DHAHDTDLEDILKKTSEAVGNKRTKKGSMQTGAYDNLGFNKKLYFNPG 446
            ::|...|:|:|.:|...:.   ....|..|....:.:...:..|..||
Human   359 EYACSCDVEEIFRKVRFSF---EQPDGRAQMPTTERVTLTRCFYLFPG 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	12/76 (16%)
		CASc	186..443	CDD:237997	60/275 (22%)
CASP1	NP_001244047.1	CARD_CASP1-like	5..87	CDD:260036	12/75 (16%)
		CASc	153..402	CDD:214521	61/276 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152744
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.700