DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dronc and casp6b.2

DIOPT Version :9

Sequence 1:	NP_524017.1	Gene:	Dronc / 39173	FlyBaseID:	FBgn0026404	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_017210076.1	Gene:	casp6b.2 / 664751	ZFINID:	ZDB-GENE-060312-12	Length:	265	Species:	Danio rerio

Alignment Length:	265	Identity:	74/265 - (27%)
Similarity:	130/265 - (49%)	Gaps:	41/265 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 RGVLLMVNIMDYPDQN-RRRIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQFFKLLTMVTSSSYV 258
            ||:.|:.|..|:.... :.|.|.:||..||:..|:||:|.:..|.:.::|:..|.:..|.::.:|
Zfish    26 RGLALIFNQKDFSLLGLKTRKGTDKDRDSLVSRFEELDFEVKAYNDYSRDKVLKEIKEVAAADHV 90

  Fly   259 QNTECFVMVLMTHGNSVEGKEKVEFCDGSV------VDMQKIKDHFQTAKCPYLVNKPKVLMFPF 317
             :.:|||.:.::||.           ||.|      :.:.:|.|.|:..||..||.|||:.::..
Zfish    91 -DADCFVCIFLSHGE-----------DGHVYANDEKIKIPEITDLFKGDKCRGLVGKPKIFIWQA 143

  Fly   318 CRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQT--EGIPSPSTNVPSLADTLVCYANTPGYVTH 380
            ||||:.|           :||.....|...|...  .|:   |..:|:.||.::||:.|.|:.:.
Zfish   144 CRGDKKD-----------DPVAPMSAEDSDDEMAVDAGV---SNTLPAGADFIMCYSTTEGFCSF 194

  Fly   381 RDLDTGSWYIQKFCQVMADHAHDTDLEDIL-----KKTSEAVGNKRTKKGSMQTGAYDNLGFNKK 440
            ||...|:||||..|::|..:....:..:||     |.:..::.:..:..|:.|...:.:: ..|:
Zfish   195 RDPLNGTWYIQDLCEIMGRYRSQLEFTNILTLVNRKVSLRSICDDLSATGTKQMPCFASM-LTKR 258

  Fly   441 LYFNP 445
            |:|.|
Zfish   259 LFFRP 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018
Dronc	NP_524017.1	CASc	186..443	CDD:237997	72/261 (28%)
casp6b.2	XP_017210076.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587218
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940