Protein Alignment Dronc and Casp9

DIOPT Version :10

• Sequence 1: NP_524017.1
• Gene: Dronc / 39173
• FlyBaseID: FBgn0026404
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_113820.1
• Gene: Casp9 / 58918
• RGDID: 61867
• Length: 454
• Species: Rattus norvegicus
• Alignment Length: 488
• Identity: 122/488 - (25%)
• Similarity: 198/488 - (40%)
• Gaps: 102/488 - (20%)

  Fly    12 KRHREHIRKNLNILVEWTNYERLAMECVQQGILTVQMLRNTQDLNGKPFNMDEKDVRVEQHRRLL 76
            :|.|..:.:.|.:...|.       ..:.:.:.|..|:.:.|...        ...|.:|.|:|:
  Rat    10 RRCRVRLVRELQVAELWD-------ALLSRELFTRDMIEDIQRAG--------SGSRRDQARQLV 59

  Fly    77 LKITQRGPTAYNLLINALRNINCLDAAVLLESVDESDSRPPFISLNERRTSRKS-ADIVDTPSPE 140
            :.:..||..|....|:.|.:......|..|:|..::..:.|     |..|.... ..:|..|...
  Rat    60 IDLETRGRQALPRFISCLEDTGQGSLASFLQSSGQAAKQDP-----EAVTPLDHLVPVVLGPMGL 119

  Fly   141 ASEGPCVSKL-RNEP-LGALTPYVGVVDG---------------PEVKKSKKIHGGDSAILGT-- 186
            .|:...|.|| .::| ||.|||   ||.|               ||..:...|..|.:..:.|
  Rat   120 KSKEQKVVKLDPSQPALGNLTP---VVLGPEELWPTRLRPEVLTPETPRPVDIGSGRAHDVCTPG 181

  Fly   187 ---------YKMQSRFNRGVLLMVNIMDYPDQN-RRRIGAEKDSKSLIHLFQELNFTIFPYGNVN 241
                     |.:.|......|::.|:...|... ..|||:..|.:.|.|.|..|.|.:    .|.
  Rat   182 KIERHADMAYTLDSDPCGHCLIINNVNFCPSSGLSTRIGSHVDCEKLQHRFCWLRFMV----EVK 242

  Fly   242 QDQFFKLLTMVTSSSYVQN-----TECFVMVLMTHG---NSVEGKEKVEFCDGSVVDMQKIKDHF 298
            .|...|  .|||:...:.:     .:|||:|:::||   :.::....|...||..|.:::|.:.|
  Rat   243 NDLTAK--KMVTALMEMAHRDHRALDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSIERIVNIF 305

  Fly   299 QTAKCPYLVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKW--PDTQTEGIP---SPS 358
            ....||.|..|||:.....|.|::.|.|        .|..:|:.::|.  .|::.:.:|   .|.
  Rat   306 NGTGCPSLGGKPKLFFIQACGGEQKDHG--------FEVAFTSSQDKAFDSDSEPDAVPYQEGPR 362

  Fly   359 T--------NVPSLADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSE 415
            |        ::|:.:|.||.|:..||:|:.||..:|||||:....|:...|...||:.:|.:.:.
  Rat   363 TLDQLDAVSSLPTPSDILVSYSTFPGFVSWRDKKSGSWYIETLDGVLEQWARSEDLQSLLLRVAN 427

  Fly   416 AVGNKRTKKGSMQTGAYDNLG--FN---KKLYF 443
            ||..|         |.|..:.  ||   |||:|
  Rat   428 AVSEK---------GVYKQIPGCFNFLRKKLFF 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	15/87 (17%)
		CASc	186..443	CDD:237997	80/294 (27%)
Casp9	NP_113820.1	CARD_CASP9	19..90	CDD:176740	15/85 (18%)
		CASc	190..452	CDD:237997	80/285 (28%)