DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dronc and Casp3

DIOPT Version :9

Sequence 1:	NP_524017.1	Gene:	Dronc / 39173	FlyBaseID:	FBgn0026404	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_037054.1	Gene:	Casp3 / 25402	RGDID:	2275	Length:	277	Species:	Rattus norvegicus

Alignment Length:	312	Identity:	77/312 - (24%)
Similarity:	126/312 - (40%)	Gaps:	77/312 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 VDGPEVK--KSKKIHGGDSAILGTYKMQSRFNRGVLLMVNIMDYPD-------QNRR-------- 212
            ||...:.  ::|.|||..|...|.| :.|.:.         ||||:       .|:.
  Rat     8 VDSKSINNFETKTIHGSKSMDSGIY-LDSSYK---------MDYPEMGLCIIINNKNFHKSTGMS 62

  Fly   213 -RIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQFFKLLTMVTSSSYVQNTECFVMVLMTHGNSVE 276
             |.|.:.|:.:|...|..|.:.:....::.:::..:|:..|:...:.:.:. ||.|:::||:
  Rat    63 ARNGTDVDAANLRETFMALKYEVRNKNDLTREEIMELMDSVSKEDHSKRSS-FVCVILSHGD--- 123

  Fly   277 GKEKVEFCDGSVVDMQKIKDHFQTAKCPYLVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTA 341
              |.|.|.....||::|:...|:...|..|..|||:.:...|||.|.|.|...:.|.  :.....
  Rat   124 --EGVIFGTNGPVDLKKLTSFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGT--DDDMAC 184

  Fly   342 QEEKWPDTQTEGIPSPSTNVPSLADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDL 406
            |:                 :|..||.|..|:..|||.:.|:...|||:||..|.::..:||..:.
  Rat   185 QK-----------------IPVEADFLYAYSTAPGYYSWRNSRDGSWFIQSLCAMLKLYAHKLEF 232

  Fly   407 EDILKKTSEAVGNK----------RTKKG-----SMQTGAYDNLGFNKKLYF 443
            ..||.:.:..|..:          ..||.     ||.|         |:|||
  Rat   233 MHILTRVNRKVATEFESFSLDATFHAKKQIPCIVSMLT---------KELYF 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018
Dronc	NP_524017.1	CASc	186..443	CDD:237997	67/287 (23%)
Casp3	NP_037054.1	CASc	37..277	CDD:214521	67/282 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910