Protein Alignment Dronc and ced-3

DIOPT Version :10

• Sequence 1: NP_524017.1
• Gene: Dronc / 39173
• FlyBaseID: FBgn0026404
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_001255708.1
• Gene: ced-3 / 178272
• WormBaseID: WBGene00000417
• Length: 503
• Species: Caenorhabditis elegans
• Alignment Length: 513
• Identity: 116/513 - (22%)
• Similarity: 192/513 - (37%)
• Gaps: 156/513 - (30%)

  Fly    46 VQMLRNTQDLNGKPFNMDEKDVRVEQHRRLLLKITQ-RGPTAYNLLINALRNINCLDAAVLLE-- 107
            :::|...|.||....:|......|.:.||.::|..| ||..|::...:|||:......|.:||
 Worm    27 LEVLIAKQVLNSDNGDMINSCGTVREKRREIVKAVQRRGDVAFDAFYDALRSTGHEGLAEVLEPL 91

  Fly   108 --SVDES--DSRPPFISLNERRT-----------SRKSADIVDTPSPEAS--------------- 142
              |||.:  :...|....:.||:           :|...|.|.:.|...|
 Worm    92 ARSVDSNAVEFECPMSPASHRRSRALSPAGYTSPTRVHRDSVSSVSSFTSYQDIYSRARSRSRSR 156

  Fly   143 ----------EGPCVSKLRNEPLGALTPYVG-------------------------------VVD 166
                      ..|.|:...::|..|.:.:.|                               .||
 Worm   157 ALHSSDRHNYSSPPVNAFPSQPSSANSSFTGCSSLGYSSSRNRSFSKASGPTQYIFHEEDMNFVD 221

  Fly   167 GPEVKKSKKIHGGDSAILGTYKMQSRFN--RGVLLMVNIMDYPDQNRRRIGAEKDSKSLIHLFQE 229
            .|.:          |.:.....|...|:  ||:.|::| .::.:|...|.|.:.|..:|.:||:.
 Worm   222 APTI----------SRVFDEKTMYRNFSSPRGMCLIIN-NEHFEQMPTRNGTKADKDNLTNLFRC 275

  Fly   230 LNFTIFPYGNVNQDQFFKLLTMVTSSSYVQNTECFVMVLMTHG--NSVEGKEKVEFCDGSVVDMQ 292
            :.:|:....|:.....  |||:...:.:..:.:..::|:::||  |.:.|.:.:.      :...
 Worm   276 MGYTVICKDNLTGRGM--LLTIRDFAKHESHGDSAILVILSHGEENVIIGVDDIP------ISTH 332

  Fly   293 KIKDHFQTAKCPYLVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPS- 356
            :|.|....|..|.|.||||::....|||:..|.|.|     :::.|             :|:|:
 Worm   333 EIYDLLNAANAPRLANKPKIVFVQACRGERRDNGFP-----VLDSV-------------DGVPAF 379

  Fly   357 ----------PSTNV---------------PSLADTLVCYANTPGYVTHRDLDTGSWYIQKFCQV 396
                      |..|.               ||.||.|:.||.|..||:.|:...|||:||..|:|
 Worm   380 LRRGWDNRDGPLFNFLGCVRPQVQQVWRKKPSQADILIAYATTAQYVSWRNSARGSWFIQAVCEV 444

  Fly   397 MADHAHDTDLEDILKKTSEAVGNKRTKKGSMQTGAYDNL---------GFNKKLYFNP 445
            .:.||.|.|:.::|.:.     ||:...| .||....|:         ...||.||.|
 Worm   445 FSTHAKDMDVVELLTEV-----NKKVACG-FQTSQGSNILKQMPEMTSRLLKKFYFWP 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	17/60 (28%)
		CASc	186..443	CDD:237997	74/295 (25%)
ced-3	NP_001255708.1	CARD	2..90	CDD:128424	18/62 (29%)
		CASc	235..496	CDD:214521	75/293 (26%)