DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dronc and csp-2

DIOPT Version :9

Sequence 1:	NP_524017.1	Gene:	Dronc / 39173	FlyBaseID:	FBgn0026404	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001370851.1	Gene:	csp-2 / 177391	WormBaseID:	WBGene00000820	Length:	826	Species:	Caenorhabditis elegans

Alignment Length:	367	Identity:	95/367 - (25%)
Similarity:	154/367 - (41%)	Gaps:	87/367 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 ESVD---ESDS-------RPPFISLNERRTSRKSADIV-----------DTPSPE-------ASE 143
            ||.|   ||||       .||..|..:...:..|:.:.           |.|:|:       |..
Worm   466 ESTDDAVESDSDDVPAPQSPPTPSPADPGPTTSSSSLTQDPASNATGFSDVPAPQAPPTPSPADP 530

  Fly   144 GPCV--SKLRNEPLGALTPYVG----------------VVDGPEVKKSKKIHGGDSAILGTYKMQ 190
            ||..  |.|..:|....|.:.|                ..||.::.:::|           |: .
Worm   531 GPTTSSSSLTQDPASNATGFSGSSPPNSFEETRMMCEDASDGKKIDETRK-----------YR-N 583

  Fly   191 SRFNRGVLLMVNIMDYPDQNRRRIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQFFKLLTMVTSS 255
            :|.::...:::|.:.:... .:|||::||.|.|..||:.|.:....|.|:...:..:.:...|.|
Worm   584 NRSSKCRAIIINNVVFCGM-EKRIGSDKDKKKLSKLFERLGYQSTSYDNLKSSEILETVRQFTQS 647

  Fly   256 SYVQNTECFVMVLMTHGNS--VEGKEKVEFCDGSVVDMQKIKDHFQTAKCPYLVNKPKVLMFPFC 318
            ::   .:..::.:|:||:.  :.|      .||..|.|..|.|...||.   |..|||.||...|
Worm   648 NH---GDSLIITIMSHGDQGLLYG------VDGVPVQMLDIIDLMCTAS---LAKKPKWLMCVCC 700

  Fly   319 RGDEYDL-----GHPKNQGNLMEPVYTAQEEKWPDTQTEGIPSPSTNVPSLADTLVCYANTPGYV 378
            |||..|.     |...|..:.....:...:.|:|..||..         |.||.||.::.:||::
Worm   701 RGDRIDRAVRCDGFIDNFFDRFPKFFQFMKSKFPSHQTSS---------SQADLLVSFSTSPGFL 756

  Fly   379 THRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSEAVGNK 420
            :.||...|:||||:..:|:.::|.||.|.|:|.:|:..|..|
Worm   757 SFRDETKGTWYIQELYRVIIENAKDTHLADLLMETNRRVVEK 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018
Dronc	NP_524017.1	CASc	186..443	CDD:237997	70/242 (29%)
csp-2	NP_001370851.1	pneumo_PspA	239..>533	CDD:411490	16/66 (24%)
		PHA03418	<475..>563	CDD:177646	17/87 (20%)
		CASc	581..824	CDD:237997	70/241 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162605
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840