DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dronc and csp-1

DIOPT Version :9

Sequence 1:	NP_524017.1	Gene:	Dronc / 39173	FlyBaseID:	FBgn0026404	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001022452.1	Gene:	csp-1 / 175007	WormBaseID:	WBGene00000819	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	347	Identity:	85/347 - (24%)
Similarity:	155/347 - (44%)	Gaps:	55/347 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 SRPPFISLNERRTSRKSADIVDTPSP------EASEG-----PCVSK---------LRNEPLGAL 158
            |.||   :...||..|..:|.: |||      ::|.|     |.:.|         .|::...:|
Worm   200 STPP---VTYHRTENKDPNIQE-PSPVEFLDVQSSLGSSMKPPILDKPTKLDDPAETRHDCSYSL 260

  Fly   159 TPYVGVVDGP--EVKKSKKIHGGDSAILGTYKMQSRFNRGVLLMVNIMDYPDQNRRRIGAEKDSK 221
            ..|......|  :.|||...|      ...|:|.|. .||.:|:::..::.:. .||:|.::|..
Worm   261 EEYDSQSRMPRTDAKKSNHKH------KYCYEMNSN-PRGTVLILSNENFKNM-ERRVGTKQDEV 317

  Fly   222 SLIHLFQELNFTIFPYGNVNQDQFFKLLTMVTSSSYVQNTECFVMVLMTHGNSVEGKEKVEFCDG 286
            :|..|||:|.:|:....|:..:   .:|..:...:.:.:|:..::.|::||   :|...|...|.
Worm   318 NLTKLFQKLQYTVICKRNLEAE---SMLEAIKEFAEMAHTDSIILFLLSHG---DGAGSVFGIDD 376

  Fly   287 SVVDMQKIKDHFQTAKCPYLVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQT 351
            ..|::.::..:.  |....|:.|||.:....|||.:.::|.|.:....:|.......:.|....:
Worm   377 MPVNVMEVSTYL--AYHQNLLLKPKWVAVSACRGGKLNMGVPVDGLPALEDKCAPISKFWNLMMS 439

  Fly   352 EGIPSPSTNVPSLADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSEA 416
            ..:|...|::.  ||.::.::.|.|:.::||.:.|:|||:..|:|...|:....|.|||.:|...
Worm   440 RIMPGTFTSLN--ADVIISFSTTDGFTSYRDEEAGTWYIKSMCKVFNKHSKTMHLLDILTETGRN 502

  Fly   417 VGNKRTKKGSMQTGAYDNLGFN 438
            |..|           |:|:..|
Worm   503 VVTK-----------YENVQGN 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018
Dronc	NP_524017.1	CASc	186..443	CDD:237997	63/253 (25%)
csp-1	NP_001022452.1	SPK	76..188	CDD:214732
csp-1	NP_001022452.1	CASc	285..533	CDD:214521	63/252 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162601
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940