DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dronc and casp3a

DIOPT Version :9

Sequence 1:	NP_524017.1	Gene:	Dronc / 39173	FlyBaseID:	FBgn0026404	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_571952.1	Gene:	casp3a / 140621	ZFINID:	ZDB-GENE-011210-1	Length:	282	Species:	Danio rerio

Alignment Length:	322	Identity:	81/322 - (25%)
Similarity:	140/322 - (43%)	Gaps:	62/322 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 GPCVSKLRNEPLGALTPYVGVVDGPEVKKSKKIHGGDSAILGTYKMQSRFNRGVLLMVNIMDYPD 208
            |.||...|.:...|..      ||....:..::.....:....|.:... |.|..:::|..::
Zfish     3 GDCVDAKRVDTTDASK------DGASASQPMQVDAKPQSHAFRYSLNYP-NIGHCIIINNKNF-- 58

  Fly   209 QNRR-----RIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQFFKLLTMVTSSSYVQNTEC--FVM 266
             :||     |.|.:.|:.:::::|::|.:.:..|.:....|..::||.|   ::..::.|  .|.
Zfish    59 -DRRTGMNPRNGTDVDAGNVMNVFRKLGYIVKVYNDQTVAQIMQVLTTV---AHDDHSRCASLVC 119

  Fly   267 VLMTHGNSVEGKEKVEFCDGSVVDMQKIKDHFQTAKCPYLVNKPKVLMFPFCRGDEYDLGHPKNQ 331
            ||::||:     |.|.|...:.||::.:...|:..:||.||.|||:.....|||.|.|.|
Zfish   120 VLLSHGD-----EGVFFGTDTSVDLKSLTSLFRGDRCPSLVGKPKLFFIQACRGTELDPG----- 174

  Fly   332 GNLMEPVYTAQEEKWPDTQTEGIPSPSTNVPSLADTLVCYANTPGYVTHRDLDTGSWYIQKFCQV 396
               :|..:|..    ||     ||.....:|..||.|..|:..|||.:.|:..||||:||..|::
Zfish   175 ---VETDHTDH----PD-----IPDGRERIPVEADFLYAYSTVPGYYSWRNTMTGSWFIQSLCEM 227

  Fly   397 MADHAHDTDLEDILKKTSEAVGNKRTKKGSMQTGAYDNLGFN-------------KKLYFNP 445
            |..:..:.:|..|:.:.:..|........:|.       ||:             |::||.|
Zfish   228 MTKYGSELELLQIMTRVNHKVALDFESTSNMP-------GFDAKKQIPCIVSMLTKEMYFTP 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018
Dronc	NP_524017.1	CASc	186..443	CDD:237997	71/276 (26%)
casp3a	NP_571952.1	CASc	39..280	CDD:237997	71/276 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910