DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dronc and Cflar

DIOPT Version :9

Sequence 1:	NP_524017.1	Gene:	Dronc / 39173	FlyBaseID:	FBgn0026404	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001276633.1	Gene:	Cflar / 12633	MGIID:	1336166	Length:	481	Species:	Mus musculus

Alignment Length:	491	Identity:	104/491 - (21%)
Similarity:	178/491 - (36%)	Gaps:	157/491 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EHIRKNLNILVEWTNYERLAME----CVQQGILTVQMLRNTQDLNGKPFNMDEK---DVRVEQHR 73
            :|:|:|.:::   ::|..|.||    ..|..:.::..|  |:|..|:.....:|   |:.:|..:
Mouse    86 DHLRRNPHLV---SDYRVLLMEIGESLDQNDVSSLVFL--TRDYTGRGKIAKDKSFLDLVIELEK 145

  Fly    74 RLLLKITQRGPTAYNLLINALRNINCLDAAVLLESVDESD------------SRPPF-ISLNERR 125
            ..|:...|     .|||...|:||:.:|....::...:|.            |.|.. |..|.|.
Mouse   146 LNLIASDQ-----LNLLEKCLKNIHRIDLNTKIQKYTQSSQGARSNMNTLQASLPKLSIKYNSRL 205

  Fly   126 TSRKSAD------------IVDTPSPEASEGPCVSKLRNEPLGALTPYVGVVDGPEVKKSKKIHG 178
            .:.:|.:            :|.|...|:              ||..|       |.:::.
Mouse   206 QNGRSKEPRFVEYRDSQRTLVKTSIQES--------------GAFLP-------PHIREE----- 244

  Fly   179 GDSAILGTYKMQSRFNRGVLLMVNIMDYPDQNRRRIGAEKDSKSLIHLFQELNFTI----FPYGN 239
                   ||:|||: ..|:.|:::.          ||  .|:|.|...|..|.:.|    ||
Mouse   245 -------TYRMQSK-PLGICLIIDC----------IG--NDTKYLQETFTSLGYHIQLFLFP--- 286

  Fly   240 VNQDQFFKLLTMVTSSSYVQNTECFVMVLMTHG--NSVEGKEKVEFCDGSVVDMQKIKDHFQTAK 302
             ......:::....|.:..|:.:.|..||::.|  .|:.|:::|.    |...:..:|:.|....
Mouse   287 -KSHDITQIVRRYASMAQHQDYDSFACVLVSLGGSQSMMGRDQVH----SGFSLDHVKNMFTGDT 346

  Fly   303 CPYLVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPSPS-TNVPSL-- 364
            ||.|..|||:...     ..|:     :.|:.:|           |:..| :..|| .||.|.
Mouse   347 CPSLRGKPKLFFI-----QNYE-----SLGSQLE-----------DSSLE-VDGPSIKNVDSKPL 389

  Fly   365 ----------ADTL--VCYANTPGYVTH--RDLDTGSWYIQKFCQVMADHAH------DTDLEDI 409
                      ||..  :|.|:    |:|  :...:.|.|:||..|.:.....      ..:|.|.
Mouse   390 QPRHCTTHPEADIFWSLCTAD----VSHLEKPSSSSSVYLQKLSQQLKQGRRRPLVDLHVELMDK 450

  Fly   410 LKKTSEAVGNKRTKKGSMQTGAYDNLGFNKKLYFNP 445
            :...:..|.:|.....|:|.      ...|||...|
Mouse   451 VYAWNSGVSSKEKYSLSLQH------TLRKKLILAP 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	23/94 (24%)
Dronc	NP_524017.1	CASc	186..443	CDD:237997	65/285 (23%)
Cflar	NP_001276633.1	Interaction with CASP8 propeptide. /evidence=ECO:0000250\|UniProtKB:O15519	6..307		57/280 (20%)
		Interaction with FADD. /evidence=ECO:0000250\|UniProtKB:O15519	6..229		32/152 (21%)
		Interaction with CASP8. /evidence=ECO:0000250\|UniProtKB:O15519	6..200		27/123 (22%)
		DED_c-FLIP_r1	6..85	CDD:260044
		DED_c-FLIP_r2	96..176	CDD:260046	21/86 (24%)
		Interaction with TRAF1 and TRAF2. /evidence=ECO:0000250\|UniProtKB:O15519	197..481		77/370 (21%)
		Interaction with CASP3. /evidence=ECO:0000250\|UniProtKB:O15519	197..436		67/318 (21%)
		Interaction with CASP8 subunits p18 and p10. /evidence=ECO:0000250\|UniProtKB:O15519	219..481		73/348 (21%)
		CASc	246..480	CDD:214521	64/286 (22%)
		Caspase	265..360		26/107 (24%)
		Interaction with CASP8. /evidence=ECO:0000250\|UniProtKB:O15519	372..481		27/120 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842783
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740