Protein Alignment Dronc and Casp9

DIOPT Version :10

• Sequence 1: NP_524017.1
• Gene: Dronc / 39173
• FlyBaseID: FBgn0026404
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_056548.2
• Gene: Casp9 / 12371
• MGIID: 1277950
• Length: 454
• Species: Mus musculus
• Alignment Length: 477
• Identity: 123/477 - (25%)
• Similarity: 198/477 - (41%)
• Gaps: 69/477 - (14%)

  Fly    10 MPKRHREHIRKNLNILVEWTNYERLAMECVQQGILTVQMLRNTQDLNGKPFNMDEKDVRVEQHRR 74
            |.:..|:.:|:....||.......|....:.:.:.|..|:.:.|...        ...|.:|.|:
Mouse     1 MDEADRQLLRRCRVRLVSELQVAELWDALLSRELFTRDMIEDIQQAG--------SGSRRDQARQ 57

  Fly    75 LLLKITQRGPTAYNLLINALRNINCLDAAVLLESVDESDSRPPF----------ISLNERRTSRK 129
            |:..:..||..|..|.|:.|.:......|.||:|..::..:.|.          :.|.....:.|
Mouse    58 LVTDLETRGRQALPLFISCLEDTGQGTLASLLQSGRQAAKQDPEAVKPLDHLVPVVLGPMGLTAK 122

  Fly   130 SADIVDTPSPEASEG---PCV--------SKLRNEPLGALTPY---VGVVDGPEVKKSKKIHG-G 179
            ...:|.....:.:.|   |.|        ::|:.|.|...||.   :|.....:|....||.| .
Mouse   123 EQRVVKLDPSQPAVGNLTPVVLGPEELWPARLKPEVLRPETPRPVDIGSGGAHDVCVPGKIRGHA 187

  Fly   180 DSAILGTYKMQSRFNRGVLLMVNIMDYPDQN-RRRIGAEKDSKSLIHLFQELNFTIFPYGNVNQD 243
            |.|    |.:.|......|::.|:...|... ..|.|:..|...|.|.|:.|.|.:    .|..|
Mouse   188 DMA----YTLDSDPCGHCLIINNVNFCPSSGLGTRTGSNLDRDKLEHRFRWLRFMV----EVKND 244

  Fly   244 QFFKLLTMVTSSSYVQN-----TECFVMVLMTHG---NSVEGKEKVEFCDGSVVDMQKIKDHFQT 300
            ...|  .|||:...:.:     .:|||:|:::||   :.::....|...||..|.::||.:.|..
Mouse   245 LTAK--KMVTALMEMAHRNHRALDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSIEKIVNIFNG 307

  Fly   301 AKCPYLVNKPKVLMFPFCRGDEYDLGH----PKNQGNLM----EP-VYTAQEEKWPDTQTEGIPS 356
            :.||.|..|||:.....|.|::.|.|.    ..:||..:    || ....||...|..|.:.:.|
Mouse   308 SGCPSLGGKPKLFFIQACGGEQKDHGFEVACTSSQGRTLDSDSEPDAVPYQEGPRPLDQLDAVSS 372

  Fly   357 PSTNVPSLADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSEAVGNKR 421
                :|:.:|.||.|:..||:|:.||..:|||||:....::...|...||:.:|.:.:.||..|.
Mouse   373 ----LPTPSDILVSYSTFPGFVSWRDKKSGSWYIETLDGILEQWARSEDLQSLLLRVANAVSAKG 433

  Fly   422 TKKGSMQTGAYDNLGFNKKLYF 443
            |.|  ...|.::.|  .|||:|
Mouse   434 TYK--QIPGCFNFL--RKKLFF 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	18/87 (21%)
		CASc	186..443	CDD:237997	80/274 (29%)
Casp9	NP_056548.2	CARD_CASP9	5..90	CDD:176740	20/92 (22%)
		CASc	190..452	CDD:237997	82/280 (29%)