DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dronc and Casp8

DIOPT Version :9

Sequence 1:	NP_524017.1	Gene:	Dronc / 39173	FlyBaseID:	FBgn0026404	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001264855.1	Gene:	Casp8 / 12370	MGIID:	1261423	Length:	500	Species:	Mus musculus

Alignment Length:	342	Identity:	84/342 - (24%)
Similarity:	145/342 - (42%)	Gaps:	53/342 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 SVDESDSRPPFISLNERRTSRKSADIVDTPSPEASEGPC---VSKLRNEPLGALTPYVGVVDGPE 169
            |::..:..||.: |:|  .|.|.|::.|:|..:.||...   |.:::|:|.|    |..:::..:
Mouse   208 SLEGREELPPSV-LDE--MSLKMAELCDSPREQDSESRTSDKVYQMKNKPRG----YCLIINNHD 265

  Fly   170 VKKSKKIHGGDSAILGTYKMQSRFNRGVLLMVNIMDYPDQNRRRIGAEKDSKSLIHLFQELNFTI 234
            ..|:::      .|....||:.                     |.|.:.|.::|...|:||:|.|
Mouse   266 FSKARE------DITQLRKMKD---------------------RKGTDCDKEALSKTFKELHFEI 303

  Fly   235 FPYGNVNQDQFFKLLTMVTSSSYVQNTECFVMVLMTHGNSVEGKEKVEFCDGSVVDMQKIKDHFQ 299
            ..|.:...::..::|....|:.: :|.:||:..:::||:    |..|...||....:..:..:|.
Mouse   304 VSYDDCTANEIHEILEGYQSADH-KNKDCFICCILSHGD----KGVVYGTDGKEASIYDLTSYFT 363

  Fly   300 TAKCPYLVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPSPSTNVPSL 364
            .:|||.|..|||:.....|:|..:..|.|...|          .|:...|......|....:|..
Mouse   364 GSKCPSLSGKPKIFFIQACQGSNFQKGVPDEAG----------FEQQNHTLEVDSSSHKNYIPDE 418

  Fly   365 ADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHA-HDTDLEDILKKTSEAVGNKRTKKGSMQ 428
            ||.|:..|.....|::||...|:||||..||.:.:.. ...|:..||...:..|.||..::...:
Mouse   419 ADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRERCPQGDDILSILTGVNYDVSNKDDRRNKGK 483

  Fly   429 TGAYDNLGFNKKLYFNP 445
            ..........|||:|.|
Mouse   484 QMPQPTFTLRKKLFFPP 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018
Dronc	NP_524017.1	CASc	186..443	CDD:237997	63/257 (25%)
Casp8	NP_001264855.1	DED_Caspase_8_r1	23..104	CDD:260041
		DD	118..199	CDD:387368
		CASc	247..499	CDD:237997	70/297 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842781
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740