DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dronc and Casp6

DIOPT Version :9

Sequence 1:	NP_524017.1	Gene:	Dronc / 39173	FlyBaseID:	FBgn0026404	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_033941.3	Gene:	Casp6 / 12368	MGIID:	1312921	Length:	276	Species:	Mus musculus

Alignment Length:	277	Identity:	74/277 - (26%)
Similarity:	132/277 - (47%)	Gaps:	42/277 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 YKMQSRFNRGVLLMVN------IMDYPDQNRRRIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQF 245
            |||..: .|||.|:.|      .:..|:  ||...|::|  :|...|.:|.|.:..:.::..::.
Mouse    20 YKMDHK-RRGVALIFNHERFFWHLTLPE--RRGTNADRD--NLTRRFSDLGFEVKCFNDLRAEEL 79

  Fly   246 FKLLTMVTSSSYVQNTECFVMVLMTHGNSVEGKEKVEFCDGSVVDMQKIKDHFQTAKCPYLVNKP 310
            ...:..|::||:: :.:||:.|.::||   ||.....:  .:.:::|.:...|:..||..||.||
Mouse    80 LLKIHEVSTSSHI-DADCFICVFLSHG---EGNHVYAY--DAKIEIQTLTGLFKGDKCQSLVGKP 138

  Fly   311 KVLMFPFCRGDEYDLGHPKNQGNLMEPVYTA-----QEEKWPDTQTEGIPSPSTNVPSLADTLVC 370
            |:.:...|||.::|:           ||...     |.:|. |..|:...:....:|:.||.|:|
Mouse   139 KIFIIQACRGSQHDV-----------PVVPLDMVDHQTDKL-DNVTQVDAASVYTLPAGADFLMC 191

  Fly   371 YANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSEAVGNKRT-------KKGSMQ 428
            |:...||.:||:...||||||..|:::|.:....:..::|...:..|..:|.       ..|..|
Mouse   192 YSVAEGYYSHRETVNGSWYIQDLCEMLARYGSSLEFTELLTLVNRKVSQRRVDFCKDPDAIGKKQ 256

  Fly   429 TGAYDNLGFNKKLYFNP 445
            ...:.:: ..|||:|.|
Mouse   257 VPCFASM-LTKKLHFCP 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018
Dronc	NP_524017.1	CASc	186..443	CDD:237997	72/273 (26%)
Casp6	NP_033941.3	CASc	20..272	CDD:214521	73/275 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842777
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840