DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dronc and Casp3

DIOPT Version :9

Sequence 1:	NP_524017.1	Gene:	Dronc / 39173	FlyBaseID:	FBgn0026404	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001271338.1	Gene:	Casp3 / 12367	MGIID:	107739	Length:	277	Species:	Mus musculus

Alignment Length:	312	Identity:	76/312 - (24%)
Similarity:	123/312 - (39%)	Gaps:	77/312 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 VDGPEVK--KSKKIHGGDSAILGTYKMQSRFNRGVLLMVNIMDYPD-------QNRR-------- 212
            ||...:.  :.|.|||..|...|.| :.|.:.         ||||:       .|:.
Mouse     8 VDSKSINNFEVKTIHGSKSVDSGIY-LDSSYK---------MDYPEMGICIIINNKNFHKSTGMS 62

  Fly   213 -RIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQFFKLLTMVTSSSYVQNTECFVMVLMTHGNSVE 276
             |.|.:.|:.:|...|..|.:.:....::.::...:|:..|:...:.:.:. ||.|:::||:
Mouse    63 SRSGTDVDAANLRETFMGLKYQVRNKNDLTREDILELMDSVSKEDHSKRSS-FVCVILSHGD--- 123

  Fly   277 GKEKVEFCDGSVVDMQKIKDHFQTAKCPYLVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTA 341
              |.|.:.....|:::|:...|:...|..|..|||:.:...|||.|.|.|...:.|        .
Mouse   124 --EGVIYGTNGPVELKKLTSFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSG--------T 178

  Fly   342 QEEKWPDTQTEGIPSPSTNVPSLADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDL 406
            .||           .....:|..||.|..|:..|||.:.|:...|||:||..|.::..:||..:.
Mouse   179 DEE-----------MACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCSMLKLYAHKLEF 232

  Fly   407 EDILKKTSEAVGNK----------RTKKG-----SMQTGAYDNLGFNKKLYF 443
            ..||.:.:..|..:          ..||.     ||.|         |:|||
Mouse   233 MHILTRVNRKVATEFESFSLDSTFHAKKQIPCIVSMLT---------KELYF 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018
Dronc	NP_524017.1	CASc	186..443	CDD:237997	66/287 (23%)
Casp3	NP_001271338.1	CASc	37..277	CDD:214521	66/282 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910