Protein Alignment Dronc and Casp2

DIOPT Version :10

• Sequence 1: NP_524017.1
• Gene: Dronc / 39173
• FlyBaseID: FBgn0026404
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_031636.1
• Gene: Casp2 / 12366
• MGIID: 97295
• Length: 452
• Species: Mus musculus
• Alignment Length: 483
• Identity: 114/483 - (23%)
• Similarity: 189/483 - (39%)
• Gaps: 108/483 - (22%)

  Fly     9 GMPKRHREHIRKNLNILVEWTNYERLAMECVQQGILTVQMLRNTQDLNGKPFNMDEKDVRVEQHR 73
            ||...|:|.::||..:|.:......|....:::.|:|::| |......|..|:         |:.
Mouse    31 GMHPDHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEM-RELIQAKGGSFS---------QNV 85

  Fly    74 RLLLKITQRGPTAYNLLINALRNI--NCLDAAVLLESVD----------ESDSRPPFI---SLNE 123
            .||..:.:|||.|::....|||..  ..|:..:|....|          :.|:..||.   |...
Mouse    86 ELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTLSDIQHVLPPLSCDYDTSLPFSVCESCPP 150

  Fly   124 RRTSRKSADIVDTPSPEASEGPCVSKLRNEPLGALTPYVGVVDGPEVKKSKKIHGGDSAILGTYK 188
            .:..|.|.|..:.........||:         .:.|..     ||..::.        ....|:
Mouse   151 HKQLRLSTDATEHSLDNGDGPPCL---------LVKPCT-----PEFYQAH--------YQLAYR 193

  Fly   189 MQSRFNRGVLLMVNIMDYPDQN--RRRIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQFFKLLTM 251
            :||: .||:.|:::.:.:..:.  ..|.|.:.|..:|:.||:.|.:.:    :|..||     |.
Mouse   194 LQSQ-PRGLALVLSNVHFTGEKDLEFRSGGDVDHTTLVTLFKLLGYNV----HVLHDQ-----TA 248

  Fly   252 VTSSSYVQN---------TECFVMVLMTHGNSVEGKEKVEFCDGSVVDMQKIKDHFQTAKCPYLV 307
            ......:||         |:..|:.|::||  |||  .:...||.::.:|::...|..|.||.|.
Mouse   249 QEMQEKLQNFAQLPAHRVTDSCVVALLSHG--VEG--GIYGVDGKLLQLQEVFRLFDNANCPSLQ 309

  Fly   308 NKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPSPST--------NVPSL 364
            ||||:.....|||||.|.|..:..|.             ..||:.|......        .:|:.
Mouse   310 NKPKMFFIQACRGDETDRGVDQQDGK-------------NHTQSPGCEESDAGKEELMKMRLPTR 361

  Fly   365 ADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSEAVGNK--------- 420
            :|.:..||...|....|:...|||||:...||.::.|.|..:.|:|.|.:..:..:
Mouse   362 SDMICGYACLKGNAAMRNTKRGSWYIEALTQVFSERACDMHVADMLVKVNALIKEREGYAPGTEF 426

  Fly   421 -RTKKGSMQTGAYDNLGFNKKLYFNPGF 447
             |.|:.|.....     ..::||..||:
Mouse   427 HRCKEMSEYCST-----LCQQLYLFPGY 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	21/89 (24%)
		CASc	186..443	CDD:237997	72/285 (25%)
Casp2	NP_031636.1	CARD_CASP2	32..118	CDD:260040	24/95 (25%)
		CASc	192..447	CDD:214521	73/286 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..349		5/34 (15%)