Protein Alignment Dronc and Casp1

DIOPT Version :10

• Sequence 1: NP_524017.1
• Gene: Dronc / 39173
• FlyBaseID: FBgn0026404
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_033937.2
• Gene: Casp1 / 12362
• MGIID: 96544
• Length: 402
• Species: Mus musculus
• Alignment Length: 411
• Identity: 91/411 - (22%)
• Similarity: 174/411 - (42%)
• Gaps: 58/411 - (14%)

  Fly    55 LNGKPFNMDEKD-------VRVEQHRRLLLKITQRGPTAYNLLINALRNINCLDAAVL-LESVDE 111
            |..:..|.:|.|       ..:::.|.|...::::||.|..:.|..:.|.:|..|.:| |:|...
Mouse    30 LEKRVLNQEEMDKIKLANITAMDKARDLCDHVSKKGPQASQIFITYICNEDCYLAGILELQSAPS 94

  Fly   112 SDSRPPFISLNERRTSRKSADIVDTPSPEASEGPCVSKLRNEPLGALTPYVGVVDGPEVKKSKKI 176
            :::   |::..:.:...          |.:||   ..:.:|:..|......|.:....::|::|:
Mouse    95 AET---FVATEDSKGGH----------PSSSE---TKEEQNKEDGTFPGLTGTLKFCPLEKAQKL 143

  Fly   177 HGGDSAILGTYKMQSRFNRGVLLMVNIMDYPDQNRRRIGAEKDSKSLIHLFQELNFTIFPYGNVN 241
            ...:.:.:  |.:.:...|..|.::...........|:||:.|.:.:..|.::|.:|:....|:.
Mouse   144 WKENPSEI--YPIMNTTTRTRLALIICNTEFQHLSPRVGAQVDLREMKLLLEDLGYTVKVKENLT 206

  Fly   242 QDQFFKLLTMVTSSSYVQNTECFVMVLMTHGNSVEGKEKVEFC----DGSVVDMQKIKDHFQ--- 299
            ..:..|.:....:....:.::...:|.|:||.. ||     .|    ...|.|:.|:...||
Mouse   207 ALEMVKEVKEFAACPEHKTSDSTFLVFMSHGIQ-EG-----ICGTTYSNEVSDILKVDTIFQMMN 265

  Fly   300 TAKCPYLVNKPKVLMFPFCRGDEYDLGHPKNQG--NLMEPVYTAQEEKWPDT--QTEGIPSPSTN 360
            |.|||.|.:||||::...|||::        ||  .|.:.|..::|:...|.  :.:||......
Mouse   266 TLKCPSLKDKPKVIIIQACRGEK--------QGVVLLKDSVRDSEEDFLTDAIFEDDGIKKAHIE 322

  Fly   361 VPSLADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSEAVGNKRTKKG 425
                .|.:...::||..|:.|....||.:|:...:.|.::|...|||||.:|...:......:
Mouse   323 ----KDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAWSCDLEDIFRKVRFSFEQPEFR-- 381

  Fly   426 SMQTGAYDNLGFNKKLYFNPG 446
             :|....|.:...|:.|..||
Mouse   382 -LQMPTADRVTLTKRFYLFPG 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	14/58 (24%)
		CASc	186..443	CDD:237997	63/267 (24%)
Casp1	NP_033937.2	CARD_CASP1-like	6..87	CDD:260036	13/56 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	98..125		6/39 (15%)
		CASc	152..400	CDD:214521	64/268 (24%)