DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dronc and Cflar

DIOPT Version :9

Sequence 1:	NP_524017.1	Gene:	Dronc / 39173	FlyBaseID:	FBgn0026404	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001029036.1	Gene:	Cflar / 117279	RGDID:	620847	Length:	480	Species:	Rattus norvegicus

Alignment Length:	420	Identity:	86/420 - (20%)
Similarity:	165/420 - (39%)	Gaps:	112/420 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EHIRKNLNILVEWTNYERLAME----CVQQGILTVQMLRNTQDLNGKPFNMDEK---DVRVEQHR 73
            :|:.::.:::   ::|..|.||    ..|..:.::..|  |:|..|:.....:|   |:.:|
  Rat    86 DHLCRSPHLV---SDYRVLLMEIGENLNQSDVSSLIFL--TKDYTGRGKVAKDKSFLDLVIE--- 142

  Fly    74 RLLLKITQRGPTAYNLLINALRNINCLDAAVLLESVDESDSRPPFISLNERRTSRKSADIVDTPS 138
              |.|:...|....|||...|::|:.:|....::...:|         ::...|..:|.....|.
  Rat   143 --LEKLNLIGSDQLNLLEKCLKSIHRIDLKTKIQKYTQS---------SQEARSNMNALQASLPK 196

  Fly   139 PEASEGPCVSKLRN----EPLGALTPYVGVVDGPEVKKSKKIHGGDSAIL-------GTYKMQSR 192
            ....|....|:|:|    ||  ....:.|:...| ||.|.:    :|.|.       .:|:|||:
  Rat   197 LSIKEHLYNSRLQNGRSKEP--RFVEHHGIQRKP-VKTSIQ----ESGIFLPPHIHEESYRMQSK 254

  Fly   193 FNRGVLLMVNIMDYPDQNRRRIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQFFKLLTMVTSSSY 257
             ..|:.|:::.          ||  .|::.|...|..|.:.:.|:...:..:..:::...::.:.
  Rat   255 -PLGICLIIDC----------IG--NDTEYLRETFTSLGYRVQPFLFPSSHEITQIVRRFSNMTQ 306

  Fly   258 VQNTECFVMVLMTHG--NSVEGKEKVEFCDGSVVDMQKIKDHFQTAKCPYLVNKPKVLMFPFCRG 320
            .|:.:.||.||::.|  .|:.|.::|.    |...::.:||.|:...||.|..|||:...
  Rat   307 HQDYDSFVCVLVSRGGSQSMMGVDQVY----SGFSLENVKDMFKGDMCPSLRGKPKLFFI----- 362

  Fly   321 DEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPSPSTNVPSLADTLVCYANTPGYVTHRDLD- 384
                    :|        |.|.|:.  ..:.:|        |::.:....:.:.....||.|.|
  Rat   363 --------QN--------YEALEDN--SLEVDG--------PAIKNVNSRHLHPRHCTTHPDADI 401

  Fly   385 -----------------TGSWYIQKFCQVM 397
                             :.|.|:||..|::
  Rat   402 FWSLCTADVSRLEQPSSSLSVYLQKLSQLL 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	21/94 (22%)
Dronc	NP_524017.1	CASc	186..443	CDD:237997	47/232 (20%)
Cflar	NP_001029036.1	DED_c-FLIP_r1	6..85	CDD:260044
		DED_c-FLIP_r2	96..176	CDD:260046	21/86 (24%)
		CASc	249..479	CDD:412128	47/231 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346256
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740