DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dronc and si:ch211-195h23.3

DIOPT Version :9

Sequence 1:	NP_524017.1	Gene:	Dronc / 39173	FlyBaseID:	FBgn0026404	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_021334238.1	Gene:	si:ch211-195h23.3 / 100170660	ZFINID:	ZDB-GENE-070912-174	Length:	1001	Species:	Danio rerio

Alignment Length:	343	Identity:	66/343 - (19%)
Similarity:	118/343 - (34%)	Gaps:	97/343 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PPELEIG-----MPKRHREHIRKNLNILVEWTNYERLAMECVQQGILTVQMLRNTQDLNGKPFNM 62
            |.||:|.     .|..:|:: |..||.|:  ::|.......::........|:..:|:..:....
Zfish   441 PLELKISDGSYLRPGGYRQY-RALLNQLI--SDYRARTESQIKHEEALWMFLQGKEDVGNQILQA 502

  Fly    63 D--------EKDVRV------EQHRRLL----------------------------LKITQRGPT 85
            |        ||:|::      :||:|.|                            ||...:...
Zfish   503 DESLSAAEQEKEVQILKNEILQQHQRGLEEQKHLEEQIIQQMKRNQEKIRRDDDQALKAKHKHEE 567

  Fly    86 AYNLLINALRNINCLDAAVLLESVDESDSRPPFISLNERRTSRKSADIVDTPSPEASEGPCVSKL 150
            |..::....:     |....:...|||      :|..|:....||  :...|..|:|.|...|:.
Zfish   568 ASWMIWKGNK-----DVGNKIVQADES------LSAVEQEKEGKS--LGSPPRAESSTGQPTSES 619

  Fly   151 RNEPLGALTP-YVGVVDGPEVKKSKKI---HGGDSAILGTYKMQSRFNRGVLLMVNIMDYPDQNR 211
            ..|    .|| .:..||..:.|.:.:.   |.|            :|...:..:|.:||...:..
Zfish   620 AEE----FTPELIQTVDEDKHKNTYRFVCPHAG------------QFQCSLTSLVFVMDGEGELL 668

  Fly   212 RRIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQFFKLLTMVTSSSYVQNTECFVMVLMTHGNSVE 276
            .|: ...|.:.|..|.|     :.|.|.:..   .|......|..::.:.|.|     :.|::::
Zfish   669 YRV-VSWDPRLLDGLGQ-----MQPAGPLYD---VKCFNGSISKLHLPHCEIF-----SEGDNMD 719

  Fly   277 GKEKVEFCDGSVVDMQKI 294
            |.....|..|::..:|.|
Zfish   720 GLAVAHFTGGNMEIVQPI 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dronc	NP_524017.1	CARD	18..106	CDD:260018	19/129 (15%)
Dronc	NP_524017.1	CASc	186..443	CDD:237997	21/109 (19%)
si:ch211-195h23.3	XP_021334238.1	P-loop_NTPase	51..307	CDD:328724
		GBP_C	315..602	CDD:293879	32/176 (18%)
		coiled coil	573..584	CDD:293879	1/15 (7%)
		coiled coil	593..602	CDD:293879	3/10 (30%)
		FIIND	645..885	CDD:316110	23/119 (19%)
		CARD_ASC_NALP1	910..991	CDD:260039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900