Protein Alignment TRIM75 and Triml1

DIOPT Version :10

• Sequence 1: NP_001382999.1
• Gene: TRIM75 / 391714
• HGNCID: 32686
• Length: 468
• Species: Homo sapiens
• Sequence 2: NP_001419727.1
• Gene: Triml1 / 290767
• RGDID: 1305337
• Length: 471
• Species: Rattus norvegicus
• Alignment Length: 491
• Identity: 144/491 - (29%)
• Similarity: 243/491 - (49%)
• Gaps: 57/491 - (11%)

Human     1 MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQCQEGHF 65
            ::.|..:..|:.|..|.|||||.|.|||.||||:||.:|:.:||.:......||.|.......||
  Rat     7 ISTADLMENLREELTCFICLDYFSSPVTTECGHSFCLTCLLKSWEEHNTPLSCPECWRTLGAPHF 71

Human    66 RSNTQLGRMIEIAK-----LLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQPPDH 125
            ::|.:|||:..|.:     :|||       ::|.:...:...|..||..::..|   :...||:|
  Rat    72 QANERLGRLANIGRQLRCQVLQS-------EDEQSNSGRTPGPSRVFSDDEQSV---INFSPPNH 126

Human   126 QGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELR-EMVENQRQELSSEFEH 189
            ..:......:|...::::....:..|:|:..:.|.:::.:.::.:..: |..:..:|.:.||:..
  Rat   127 GMNRAYFSSEAEEQHKEKLQDIVNILRKRKKEAQAILNHEKERVMLCKQEETKTCKQVVVSEYMK 191

Human   190 LNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELSELSELELLSQIK- 253
            ::|||..|:|..|..|.:|||:|.:||..|....:.....:...:.::..:.:...||...:::
  Rat   192 MHQFLKEEEQLQLQLLEKEEKENVKKLRENEIHLTQQVRRINKMIGRIESICQNLTLESFEEVRG 256

Human   254 --IFYESENESSP--SIFSIHLKRDGCSFPPQYSALQRIIKKFKVEIILDPETAHPNLIVSEDKK 314
              ..|||.....|  :|..:.|.|        .:.::.:::||..:|.|||.||:..|::|:|.|
  Rat   257 AMDRYESLLFQCPETTITELSLCR--------ITGMREMLRKFSTDITLDPATANAYLLLSDDLK 313

Human   315 RVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGDKSEWAIGICKDSLPTKAR--RP 377
            .||:...||::|..|:||.....|||...|..|||:||:|||.|:||.:||||||:..|..  :|
  Rat   314 SVRYGGTKQQLPDNPERFDQSATVLGAQIFTCGRHYWEVEVGKKTEWEVGICKDSVNRKGNLPKP 378

Human   378 SSAQQECWRIELQDD----------GYHAPGAFPTPLLLEVKARAIGIFLDYEMGEISFYNMAEK 432
            .........:::.||          |.|          :......:|:||||:.|.|:|||:.::
  Rat   379 PGDLFSLIGLKIGDDYSLWVSSPLKGQH----------VREPVHKVGVFLDYDSGHIAFYNVTDE 433

Human   433 SHICTF-TDTFTGPLRPYF-----YVGPDSQPLRIC 462
            |.|.:| ..:|...|||.|     ..|.::.||.||
  Rat   434 SLIYSFPPSSFHEALRPIFSPCLPNEGTNTDPLIIC 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRIM75	NP_001382999.1	RING-HC_TRIM60-like_C-IV	13..60	CDD:438269	23/46 (50%)
		Bbox2_TRIM60-like	95..133	CDD:380849	7/37 (19%)
		235kDa-fam	<152..>237	CDD:130673	20/85 (24%)
		SPRY_PRY_TRIM75	276..462	CDD:294001	68/203 (33%)
Triml1	NP_001419727.1	RING_Ubox	15..74	CDD:473075	26/58 (45%)
		SPRY_PRY_C-I_1	294..469	CDD:293968	66/184 (36%)