DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nudE and ndel1a

DIOPT Version :9

Sequence 1:	NP_001097569.1	Gene:	nudE / 39169	FlyBaseID:	FBgn0036059	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_958501.1	Gene:	ndel1a / 394244	ZFINID:	ZDB-GENE-040115-2	Length:	344	Species:	Danio rerio

Alignment Length:	304	Identity:	109/304 - (35%)
Similarity:	160/304 - (52%)	Gaps:	43/304 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PMFNSVEDECRYWKERSKQYHKEWTDVKQEYDEFVEQSREMEIEMDATLDQKQSIIKDLTAKLTM 69
            |.|.:.|:|..:||..|.:|.|.:.:.::|..||.|.|||:|.|::..|.|.:..|:||.|....
Zfish     7 PKFTTKEEEIDFWKALSLKYKKSYKEAQEELLEFQEGSRELETELETQLGQAEHRIRDLQADNQR 71

  Fly    70 FERENESLKLKLESHGIDMSNMEKQLETVKKD-------RDTMKVYLRQLEQKNDDLERAHRILN 127
            .:.|.:|||.|||   ...:...||:..::.|       ::.:..|:|:|||.|||||||.|...
Zfish    72 LQHELDSLKEKLE---YQYAQSYKQISVLEDDLSQTRGIKEQLHKYVRELEQANDDLERAKRATI 133

  Fly   128 ESIENFEKMLDQAYEKNALLELEVDEKGLLQEKLQRLMDETRDLKQELNVKSRFTPV--VNGTSV 190
            .|:|:||:.|:||.|:||.||.|:|||..|...:|||.||.|||:|||.|:...:.|  ::..|.
Zfish   134 TSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRDTRSEVTRMSAPSS 198

  Fly   191 PTANDTNTVNSSMNSSASLPNGIVANGELVKHDNAVATRATSVSVNALNGSLVNRNEYNQQHSLK 255
            ||. |.:..:|::.:|.|||                   ||.:|.|.       .|.:..|..|.
Zfish   199 PTP-DNDKTDSAVQASLSLP-------------------ATPLSKNL-------DNAFTSQTVLA 236

  Fly   256 NPENQINGNSMNPSSRTTALNIVADMLRKLNWDKALLCPECEKF 299
            |.....   ::.||:|.:|||||.|:|||:...::.|. .|..|
Zfish   237 NGSTNA---ALTPSARISALNIVGDLLRKVGALESKLA-ACRNF 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nudE	NP_001097569.1	NUDE_C	129..>177	CDD:282704	28/47 (60%)
ndel1a	NP_958501.1	TolA_bind_tri	42..98	CDD:292947	21/58 (36%)
		NUDE_C	135..308	CDD:282704	62/173 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..209		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..344
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596578
Domainoid	1	1.000	83	1.000	Domainoid score	I8283
eggNOG	1	0.900	-	-		E1_KOG1853
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H32567
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4425
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1082224at2759
OrthoFinder	1	1.000	-	-		FOG0002325
OrthoInspector	1	1.000	-	-		otm25440
orthoMCL	1	0.900	-	-		OOG6_104683
Panther	1	1.100	-	-	O	PTHR10921
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1753
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760